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Immunohistochemical localization of myelin-associated glycoprotein isoforms during the development in the mouse brain
- Source :
- Brain Research. 563:288-292
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- The developmental changes in localization of myelin-associated glycoprotein (MAG) isoforms in the mouse brain were demonstrated by an immunohistochemical method using antisera specific to two MAG isoforms. The antiserum to the large isoform of MAG (L-MAG) stained the myelin sheaths and the cytoplasm of oligodendroglia in the active myelinating stage in the mouse central nervous system. However, the antiserum to the small isoform of MAG (S-MAG) stained only myelin sheaths in the adult stage. These findings suggest that L-MAG plays an important role in active myelination.
- Subjects :
- Male
Gene isoform
Central nervous system
Mice, Inbred Strains
Biology
Mice
Myelin
Isomerism
medicine
Animals
Molecular Biology
Brain Chemistry
chemistry.chemical_classification
Antiserum
Myelin-associated glycoprotein
General Neuroscience
Brain
Immunohistochemistry
Oligodendrocyte
Cell biology
Myelin-Associated Glycoprotein
Oligodendroglia
medicine.anatomical_structure
nervous system
chemistry
Neuroglia
Neurology (clinical)
Glycoprotein
Neuroscience
Myelin Proteins
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 563
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....0f64a3150399469af617ac195863d407