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Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2019
- Publisher :
- Portland Press Ltd., 2019.
-
Abstract
- The immunological, biochemical and molecular mechanisms associated with poor immune recovery are far from known, and metabolomic profiling offers additional value to traditional soluble markers. Here, we present novel and relevant data that could contribute to better understanding of the molecular mechanisms preceding a discordant response and HIV progression under suppressive combined antiretroviral therapy (cART). Integrated data from nuclear magnetic resonance (NMR)-based lipoprotein profiles, mass spectrometry (MS)-based metabolomics and soluble plasma biomarkers help to build prognostic and immunological progression tools that enable the differentiation of HIV-infected subjects based on their immune recovery status after 96 weeks of suppressive cART. The metabolomic signature of ART-naïve HIV subjects with a subsequent late immune recovery is the expression of pro-inflammatory molecules and glutaminolysis, which is likely related to elevate T-cell turnover in these patients. The knowledge about how these metabolic pathways are interconnected and regulated provides new targets for future therapeutic interventions not only in HIV infection but also in other metabolic disorders such as human cancers where glutaminolysis is the alternative pathway for energy production in tumor cells to meet their requirement of rapid proliferation.
- Subjects :
- Adult
Male
0301 basic medicine
Cart
Magnetic Resonance Spectroscopy
Immune recovery
Anti-HIV Agents
Glutamine
Lipoproteins
HIV Infections
Inflammation
NMR-based lipoprotein profile
Mass Spectrometry
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Metabolomics
MS-based metabolomics
medicine
Humans
Glutaminolysis
business.industry
HIV
General Medicine
Middle Aged
Metabolic pathway
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
HIV-1
Alternative complement pathway
CD4+ T-cell turnover
medicine.symptom
business
Biomarkers
Poor immune recovery
Follow-Up Studies
Lipoprotein
Subjects
Details
- ISSN :
- 14708736 and 01435221
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Clinical Science
- Accession number :
- edsair.doi.dedup.....0f5e2bedbe1ddcf6e3410da7fad12371