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Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development
- Source :
- Mechanisms of development. 51(2-3)
- Publication Year :
- 1995
-
Abstract
- The Wnt gene family encodes a set of signalling molecules implicated in the development of a wide range of organisms. We have recently cloned partial cDNA sequences of murine Wnt-11 and Wnt-12. Here, we describe the spatio-temporal expression patterns of both genes during mouse embryogenesis. Wnt-11 expression is first detected within the truncus arteriosus from 8.25 dpc. By 9.5 dpc, Wnt-11 expression is detected in the somites at the medial junction of the dermatome and the myotome. Wnt-11 transcripts are also detected in limb bud mesenchyme from the time the bud is first visible. Wnt-12 is detected in the apical ectodermal ridge from 10.5 dpc. The implications of these expression patterns are discussed.
- Subjects :
- Apical ectodermal ridge
Embryology
Reading Frames
DNA, Complementary
Mesenchyme
Molecular Sequence Data
Biology
Limb bud
Embryonic and Fetal Development
Mice
Myotome
Pregnancy
Proto-Oncogene Proteins
medicine
Gene family
Animals
Amino Acid Sequence
Gene
In Situ Hybridization
Glycoproteins
Mice, Inbred ICR
Base Sequence
Sequence Homology, Amino Acid
Embryogenesis
Wnt signaling pathway
Gene Expression Regulation, Developmental
Proteins
Molecular biology
Wnt Proteins
medicine.anatomical_structure
embryonic structures
Female
Developmental Biology
Subjects
Details
- ISSN :
- 09254773
- Volume :
- 51
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Mechanisms of development
- Accession number :
- edsair.doi.dedup.....0f5338966224269e5045ca854a797580