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Reduction of Postprandial Glycemic Excursions in Patients with Type 1 Diabetes: A Novel Human Insulin Formulation versus a Rapid-Acting Insulin Analog and Regular Human Insulin
- Source :
- Journal of Diabetes Science and Technology. 5:681-686
- Publication Year :
- 2011
- Publisher :
- SAGE Publications, 2011.
-
Abstract
- Evaluation of postprandial glycemic excursions in patients with type 1 diabetes with three prandial insulins: VIAject™ (Linjeta™), an ultra-fast insulin (UFI); insulin lispro (LIS); and regular human insulin (RHI).After stabilization of preprandial glycemia, 18 patients received a subcutaneous injection with an individualized insulin dose prior to a meal.Injection of UFI resulted in a more rapid insulin absorption than with either LIS or RHI (time to half-maximal insulin levels: 13.1 ± 5.2 vs 25.4 ± 7.6 and 38.4 ± 19.5 min; p = .001 vs LIS and p.001 vs RHI, LIS vs. RHI p.001). Maximal postprandial glycemia was lower with UFI (0-180 min; 157 ± 30 mg/dl; p = .002 vs RHI) and LIS (170 ± 42 mg/dl; p = .668 vs RHI) than after RHI (191 ± 46 mg/dl; RHI vs LIS p = .008). The difference between maximum and minimum glycemia was smaller with UFI (70 ± 17 mg/dl) than with either RHI (91 ± 33 mg/dl; p = .007 vs UFI) or LIS (89 ± 18 mg/dl; p = .011 vs UFI). Also, the area under the blood glucose profile was lower with UFI than with RHI (0-180 min; 21.8 ± 5.8 vs 28.4 ± 7.6 g·min/dl; p.001).The rapid absorption of UFI results in a reduction of postprandial glycemic excursions.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Biomedical Engineering
Bioengineering
Absorption
Subcutaneous injection
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Insulin
Insulin lispro
Glycemic
Type 1 diabetes
Meal
Insulin Lispro
business.industry
Middle Aged
Postprandial Period
medicine.disease
Diabetes Mellitus, Type 1
Treatment Outcome
Endocrinology
Postprandial
Area Under Curve
Female
Original Article
business
medicine.drug
Subjects
Details
- ISSN :
- 19322968
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Science and Technology
- Accession number :
- edsair.doi.dedup.....0f4a5f3bd372d85217c3bb45120d22e4