Supplementary Figure 3 from The Chemokine (CCL2–CCR2) Signaling Axis Mediates Perineural Invasion

A. A schematic of the DRG and cancer cell co-culture model depicts that cancer cells initially attach to DRG neurites. Over time, the cancer cells migrate along the neurites towards the DRG and also proliferate. B. Close up views of the photomicrographs from Figure 3 show an association between the shControl PC-3 cells and the DRG neurites (Figure 3A), but fewer associations between the shCCR-2 PC-3 cells and DRG neurites (Figure 3B).