Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria

Authors :: Pierre Krausz
Robert Granet
C. Kaldapa
Vincent Sol
P. Branland
Bernard Verneuil
Laboratoire de Chimie des Substances Naturelles (LCSN)
Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)
Source :: Bioorganic and Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry Letters, Elsevier, 1998, 8 (21), pp.3007-3010. ⟨10.1016/S0960-894X(98)00536-8⟩
Publication Year :: 1999
Abstract: Novel porphyrins bearing nitro groups and glucosyl moieties were synthesized. The antibacterial activity of these compounds on Escherichia coli and Staphylococcus aureus is described. Results reveal that their photocytotoxicity is markedly dependent on the nature, the number and the linking position of the glycosyl moieties and nitro groups controlling their amphiphilic characters.

Subjects :: Staphylococcus aureus
Glycosylation
Porphyrins
Stereochemistry
[SDV]Life Sciences [q-bio]
Gram-positive bacteria
Clinical Biochemistry
Nitro compound
Pharmaceutical Science
medicine.disease_cause
01 natural sciences
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
Drug Discovery
medicine
Escherichia coli
[CHIM]Chemical Sciences
Glycosyl
Molecular Biology
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Antibacterial agent
chemistry.chemical_classification
0303 health sciences
biology
[CHIM.ORGA]Chemical Sciences/Organic chemistry
010405 organic chemistry
Chemistry
Organic Chemistry
biology.organism_classification
0104 chemical sciences
Anti-Bacterial Agents
carbohydrates (lipids)
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Photochemotherapy
Nitro
Molecular Medicine
Antibacterial activity
Bacteria

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