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High-speed Ultrahigh Resolution Optical Coherence Tomography before and after Ranibizumab for Age-related Macular Degeneration
- Source :
- Ophthalmology. 116:956-963
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Objective To evaluate intraretinal anatomy in patients with exudative age-related macular degeneration (AMD) using high-speed ultrahigh resolution optical coherence tomography (hsUHR-OCT) before and 1 month after intravitreal injection of ranibizumab. Design Retrospective case series. Participants Twelve eyes of 12 patients. Methods A broad bandwidth superluminescent diode laser light source and spectral/Fourier domain signal detection were used to create a prototype hsUHR-OCT instrument with 3.5 μm axial image resolution and approximately 25,000 lines/second acquisition speed. Twelve eyes of 12 patients with exudative AMD were imaged with hsUHR-OCT before and 1 month after intravitreal ranibizumab injection. High pixel density and raster-scanned 3-dimensional (3D) OCT data sets were generated. Three-dimensional imaging software was used to calculate subretinal/retinal pigment epithelium fluid volume and volume of the fibrovascular lesion. Main Outcome Measures Qualitative and quantitative analysis of hsUHR-OCT images and 3D data sets. Results All eyes had some degree of normalization of macular contour after intravitreal ranibizumab. The inner/outer photoreceptor segment junction visualized on hsUHR-OCT was discontinuous, overlying the fibrovascular lesion in all 12 of 12 eyes both before and after treatment; 9 of 12 eyes had focal areas of thinning of the outer nuclear layer, which remained after treatment. Volumetric measurements were possible in 8 of 12 eyes with 3D-rendering software. Fibrovascular lesion volume did not change significantly after treatment. Conclusions hsUHR-OCT is capable of unprecedented imaging speed and resolution, making it a valuable instrument in measuring in vivo intraretinal pathology. All 12 eyes had some normalization of macular contour. Fibrovascular lesion volume did not change significantly 1 month after treatment, suggesting that ranibizumab does not cause much initial regression of preexisting neovascular tissue. Photoreceptor abnormalities remained in all patients after treatment of wet AMD, suggesting that although ranibizumab improves overall retinal architecture, some photoreceptor damage may be irreversible. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.
- Subjects :
- Male
medicine.medical_specialty
Visual acuity
genetic structures
Visual Acuity
Angiogenesis Inhibitors
Antibodies, Monoclonal, Humanized
Retina
Article
Injections
Macular Degeneration
chemistry.chemical_compound
Imaging, Three-Dimensional
Optical coherence tomography
Ranibizumab
Ophthalmology
Image Processing, Computer-Assisted
medicine
Humans
Fluorescein Angiography
Aged
Retrospective Studies
Aged, 80 and over
medicine.diagnostic_test
business.industry
Antibodies, Monoclonal
Retinal
Middle Aged
Macular degeneration
medicine.disease
Fluorescein angiography
eye diseases
Surgery
Vitreous Body
medicine.anatomical_structure
chemistry
Female
sense organs
medicine.symptom
business
Tomography, Optical Coherence
medicine.drug
Retinopathy
Subjects
Details
- ISSN :
- 01616420
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- Ophthalmology
- Accession number :
- edsair.doi.dedup.....0f409a46512297974cd400dab6bf8b4c