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Genome-Wide Linkage Analysis of the Risk of Contracting a Bloodstream Infection in 47 Pedigrees Followed for 23 Years Assembled From a Population-Based Cohort (the HUNT Study)
- Source :
- Critical care medicine. 48(11)
- Publication Year :
- 2020
-
Abstract
- Objectives Bloodstream infection is an important cause of death worldwide. The main objective of this study was to identify genetic loci linked to risk of contracting a bloodstream infection. Design Genome-wide linkage analysis. Setting Population-based, Norwegian cohort, followed between 1995 and 2017. Subjects Among 69,423 genotyped subjects, there were 47 families with two or more second-degree relatives with bloodstream infection in the follow-up period. There were 365 subjects in these families, of which 110 were affected. Interventions None. Measurements and main results The cohort was genotyped using Illumina HumanCoreExome (Illumina, San Diego, CA) arrays. Before linkage analysis, single-nucleotide polymorphisms were pruned and clumped. In nonparametric linkage analysis using an exponential model, we found three loci with a suggestive linkage to bloodstream infection, all on chromosome 4, at 46.6 centimorgan (logarithm of odds, 2.3), 57.7 centimorgan (logarithm of odds, 3.2), and 70.0 centimorgan (logarithm of odds, 2.1). At the peak of the lead region are three genes: TLR10, TLR1, and TLR6. Conclusions Variations in the TLR10/1/6 locus appear to be linked with the risk of contracting a bloodstream infection.
- Subjects :
- Adult
Male
Genetic Linkage
Locus (genetics)
Pedigree chart
Critical Care and Intensive Care Medicine
Polymorphism, Single Nucleotide
Odds
Cohort Studies
03 medical and health sciences
Centimorgan
Young Adult
0302 clinical medicine
Genetic linkage
Risk Factors
Sepsis
Medicine
Humans
Genetic Predisposition to Disease
Cause of death
Aged
Genetics
Aged, 80 and over
business.industry
Norway
030208 emergency & critical care medicine
Middle Aged
Pedigree
Chromosome 4
030228 respiratory system
Genetic Loci
Cohort
Female
Chromosomes, Human, Pair 4
business
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15300293
- Volume :
- 48
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Critical care medicine
- Accession number :
- edsair.doi.dedup.....0f1cad0060bf00d3266a8ef08f08a33d