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Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene
- Source :
- Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 22(5)
- Publication Year :
- 2015
-
Abstract
- Introduction: Apolipoprotein E (ApoE) 4 isoform has been associated with elevated levels of cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs), meanwhile several polymorphisms in the LDL receptor ( LDLR) gene have been associated with increased levels of total cholesterol and LDL-C. Material and Methods: We studied 400 women from Southwest Mexico. Anthropometric features and biochemical profile were evaluated, and genotyping of single nucleotide polymorphisms rs429358 and rs7412 in the APOE gene and rs688 in the LDLR gene was determined by TaqMan assays. Results: We found significant association between LDL-C (odds ratio [OR] = 3.3, 95% confidence interval [CI]: 1.9-5.7) and marginal association with TG (OR = 1.7, 95% CI: 1.0-2.9) of atherogenic risk in women carriers of the ApoE4 isoform compared to ApoE3. The TT genotype of rs688 in the LDLR gene was not found to be associated with elevated levels of total cholesterol or LDL-C. Conclusion: Our results show that carrier women of the ApoE4 isoform are more likely to have elevated levels of LDL-C and therefore increased risk of developing atherosclerosis.
- Subjects :
- 0301 basic medicine
Gene isoform
Apolipoprotein E
Adult
medicine.medical_specialty
Heterozygote
Apolipoprotein E4
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
03 medical and health sciences
chemistry.chemical_compound
Internal medicine
Genotype
Odds Ratio
Medicine
Humans
Genotyping
Mexico
Triglycerides
Genetics
business.industry
Cholesterol
Hematology
General Medicine
Odds ratio
Cholesterol, LDL
Middle Aged
Atherosclerosis
Up-Regulation
030104 developmental biology
Endocrinology
chemistry
Receptors, LDL
LDL receptor
lipids (amino acids, peptides, and proteins)
Female
business
Subjects
Details
- ISSN :
- 19382723
- Volume :
- 22
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
- Accession number :
- edsair.doi.dedup.....0f1c6ab1a15fd05dd9b156c25697aab4