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Influence of Antiretroviral Therapy and Periodontal Disease on Human Salivary Beta-Defensin 2 in Patients Infected with HIV
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2014
- Publisher :
- Bentham Science Publishers Ltd., 2014.
-
Abstract
- Studies have addressed periodontal disease biomarkers in salivary proteins associated with innate immunity, mostly due to the alteration in the concentration of many of these proteins in the presence of inflammation. On the other hand, some systemic diseases can modify salivary protein concentrations, which may change their importance or role as specific biomarkers. To study the relationship between periodontal disease and concentrations of human beta-defensin 2 (HBD-2) in the saliva of patients infected and not infected with HIV. To evaluate the association between HBD-2 salivary concentration and viral load, the TCD4+ lymphocyte count (LTCD-4+) and the use of antiretroviral therapy (ART) was assessed in HIVinfected patients. Concentrations of HBD-2 were measured in 48 patients not infected with HIV and 53 HIV-infected patients by ELISA, and these data were compared according to periodontal status. Within the group of HIV-infected patients, measures of HBD-2 were assessed according to viral load, LTCD-4+ count and the use of ART. Concentrations of salivary HBD-2 were associated with periodontal disease in non-HIV-infected patients. In HIV-infected patients, salivary HBD-2 was associated with serum status and the use of ART, but it was not related to the periodontal condition. The presence of HBD-2 in the saliva of HIV-infected patients showed no correlations with LTCD-4+ count or viral load. HBD-2 could be a periodontal biomarker in non-HIV-infected patients, but in HIV-infected patients, while salivary HBD- 2 was influenced by the serum status and ART use, it was not correlated with the periodontal condition.
- Subjects :
- Adult
Male
DOENÇAS PERIODONTAIS
Saliva
beta-Defensins
Anti-HIV Agents
Lymphocyte
HIV Infections
Inflammation
Periodontal disease
Virology
medicine
Humans
Periodontal Diseases
Innate immune system
business.industry
Beta-defensin 2
Middle Aged
Viral Load
CD4 Lymphocyte Count
Infectious Diseases
medicine.anatomical_structure
Case-Control Studies
Immunology
Biomarker (medicine)
Female
medicine.symptom
business
Viral load
Biomarkers
Subjects
Details
- ISSN :
- 1570162X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Current HIV Research
- Accession number :
- edsair.doi.dedup.....0f1abe98be4123784c697450cb8c5d0f