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Synovial fluid levels of VEGF and FGF-2 before and after intra-articular injection of hyaluronic acid in patients with temporomandibular disorders: a short-term study
- Source :
- British Journal of Oral and Maxillofacial Surgery. 59:64-69
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Our purpose was to measure the temporomandibular joint (TMJ) synovial fluid (SF) levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) before and after intra-articular injection of hyaluronic acid (HA) and to investigate the possible mechanism involved in the therapeutic value of HA. We analysed the synovial fluid of 30 patients with unilateral internal derangement (ID) or osteoarthritis (OA) of the TMJ (confirmed by magnetic resonance imaging and cone-beam computed tomography) and recorded clinical signs and symptoms including maximal mouth opening, subjective joint pain, and joint noise at the patient's each visit. All clinical signs significantly improved after injection of HA, and there was no significant difference between ID and OA groups. In synovial fluid parameters, the concentration of VEGF was significantly higher before treatment with HA than after treatment, but there was no significant difference in the concentration of FGF-2 between before and after treatment. The study findings suggest intra-articular injection of HA may reduce the synovitis and improve the internal state of the TMJ in a short period.
- Subjects :
- Vascular Endothelial Growth Factor A
medicine.medical_specialty
Urology
Osteoarthritis
Injections, Intra-Articular
chemistry.chemical_compound
Synovitis
Synovial Fluid
Hyaluronic acid
medicine
Humans
Synovial fluid
Hyaluronic Acid
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Temporomandibular Joint Disorders
medicine.disease
Temporomandibular joint
Fibroblast Growth Factors
Vascular endothelial growth factor
medicine.anatomical_structure
Otorhinolaryngology
chemistry
Joint pain
Fibroblast Growth Factor 2
Surgery
Oral Surgery
medicine.symptom
business
Subjects
Details
- ISSN :
- 02664356
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- British Journal of Oral and Maxillofacial Surgery
- Accession number :
- edsair.doi.dedup.....0f158b3df63a66fee79648a1921fb3a5