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Evaluating the efficacy of tissue-engineered human amniotic membrane in the treatment of myocardial infarction
- Source :
- Regenerative Medicine. 14:113-126
- Publication Year :
- 2019
- Publisher :
- Future Medicine Ltd, 2019.
-
Abstract
- Aim: The aim of this study was to evaluate the efficacy of tissue-engineered amniotic membrane (AM) in the treatment of myocardial infarction lesions. Materials & methods: 20 rats were subjected to coronary arterial ligation in order to induce myocardial infarction injury. Decellularized human AMs were seeded with 2 × 105 adipose-derived mesenchymal stem cells and were implanted in the infarcted hearts. Results & conclusion: Histological and immunohistochemical evaluations indicated the regeneration of cardiomyocytes and reduction of inflammation and fibrosis in the patch-implanted group compared with a control group, 14 days after the surgery. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick-end labeling assay was suggestive for apoptosis reduction in the patch-implanted specimens. This study suggested that human AM can be developed into a novel treatment for treating postmyocardial infarction.
- Subjects :
- Embryology
Pathology
medicine.medical_specialty
medicine.medical_treatment
0206 medical engineering
Myocardial Infarction
Biomedical Engineering
Infarction
Apoptosis
02 engineering and technology
Regenerative Medicine
03 medical and health sciences
Fibrosis
medicine
Animals
Humans
Myocytes, Cardiac
Amnion
Myocardial infarction
030304 developmental biology
0303 health sciences
Decellularization
Tissue Engineering
business.industry
Regeneration (biology)
Mesenchymal stem cell
Stem-cell therapy
medicine.disease
020601 biomedical engineering
Rats
Immunohistochemistry
business
Subjects
Details
- ISSN :
- 1746076X and 17460751
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Regenerative Medicine
- Accession number :
- edsair.doi.dedup.....0f0f3966d42aa2888959921780d8d8da