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How social structures, space, and behaviors shape the spread of infectious diseases using chikungunya as a case study
- Source :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, ⟨10.1073/pnas.1611391113⟩, Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences of the United States of America, 2016, ⟨10.1073/pnas.1611391113⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; Whether an individual becomes infected in an infectious disease outbreak depends on many interconnected risk factors, which may relate to characteristics of the individual (e.g., age, sex), his or her close relatives (e.g., household members), or the wider community. Studies monitoring individuals in households or schools have helped elucidate the determinants of transmission in small social structures due to advances in statistical modeling; but such an approach has so far largely failed to consider individuals in the wider context they live in. Here, we used an outbreak of chikungunya in a rural community in Bangladesh as a case study to obtain a more comprehensive characterization of risk factors in disease spread. We developed Bayesian data augmentation approaches to account for uncertainty in the source of infection, recall uncertainty, and unobserved infection dates. We found that the probability of chikungunya transmission was 12% [95% credible interval (CI): 8–17%] between household members but dropped to 0.3% for those living 50 m away (95% CI: 0.2–0.5%). Overall, the mean transmission distance was 95 m (95% CI: 77–113 m). Females were 1.5 times more likely to become infected than males (95% CI: 1.2–1.8), which was virtually identical to the relative risk of being at home estimated from an independent human movement study in the country. Reported daily use of antimosquito coils had no detectable impact on transmission. This study shows how the complex interplay between the characteristics of an individual and his or her close and wider environment contributes to the shaping of infectious disease epidemics.
- Subjects :
- 0301 basic medicine
Male
Time Factors
Climate
Basic Reproduction Number
Context (language use)
Disease
medicine.disease_cause
Disease Outbreaks
03 medical and health sciences
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
medicine
Credible interval
Humans
Computer Simulation
Chikungunya
Social Behavior
Bangladesh
Family Characteristics
Multidisciplinary
Models, Statistical
Geography
Transmission (medicine)
Outbreak
Biological Sciences
Virology
Markov Chains
3. Good health
030104 developmental biology
Infectious disease (medical specialty)
Relative risk
Chikungunya Fever
Female
Monte Carlo Method
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, ⟨10.1073/pnas.1611391113⟩, Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences of the United States of America, 2016, ⟨10.1073/pnas.1611391113⟩
- Accession number :
- edsair.doi.dedup.....0f0b56e984e9130a0c8fed63455b3eba