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Molecular genomic characterization of severe fever with thrombocytopenia syndrome virus isolates from South Korea
- Source :
- Journal of Microbiology. 57:927-937
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne emerging infectious disease caused by the SFTS virus (SFTSV) and is a threat to public health due to its high fatality rate. However, details on tick-to-human transmission of SFTSV are limited. In this study, we determined the whole-genome sequence of a South Korean SFTSV strain (CUK-JJ01), compared it to those of other recent human SFTSV isolates, and identified the genetic variations and relationships among the SFTSV strains. The genome of CUK-JJ01 was consistent with the genome of other members of the genus Phlebovirus, including the large (L), medium (M), and small (S) segments of 6368, 3378, and 1744 nucleotides, respectively. Based on amino acid sequences of the M and S segments, which are used to distinguish the six SFTSV genotypes, CUK-JJ01 was classified as genotype B. Segment analysis revealed that the L, M, and S segments were 97.49%, 97.18%, and 97.94% similar to those of KAJNH2/2013/Korea, ZJZHSH-FDE/2012/China, and KADGH/2013/Korea, respectively. Currently, only few studies on SFTSV have been conducted in Korean population and most were limited to serological analysis. Although the present study has limitations in terms of number of sample analyzed, the findings may serve as basis to understand the transmission and spread of SFTSV, as well as for the development of diagnostic and detection methods for viral recombinants by comparing the whole genome sequence of SFTSV isolates from South Korea and that of foreign isolates.
- Subjects :
- Phlebovirus
China
Genotype
Bunyaviridae Infections
Applied Microbiology and Biotechnology
Microbiology
Serology
03 medical and health sciences
Republic of Korea
Genetic variation
medicine
Humans
Amino Acid Sequence
Phylogeny
030304 developmental biology
0303 health sciences
biology
030306 microbiology
SFTS virus
General Medicine
biology.organism_classification
medicine.disease
Virology
Severe fever with thrombocytopenia syndrome
Phlebotomus Fever
Emerging infectious disease
Severe fever with thrombocytopenia syndrome virus
Subjects
Details
- ISSN :
- 19763794 and 12258873
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Journal of Microbiology
- Accession number :
- edsair.doi.dedup.....0f0a7493435057a9f368c3d76a9cf67b