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Nerve Guidance Conduits from Aligned Nanofibers: Improvement of Nerve Regeneration through Longitudinal Nanogrooves on a Fiber Surface
- Source :
- ACS Applied Materials & Interfaces. 7:7189-7196
- Publication Year :
- 2015
- Publisher :
- American Chemical Society (ACS), 2015.
-
Abstract
- A novel fibrous conduit consisting of well-aligned nanofibers with longitudinal nanogrooves on the fiber surface was prepared by electrospinning and was subjected to an in vivo nerve regeneration study on rats using a sciatic nerve injury model. For comparison, a fibrous conduit having a similar fiber alignment structure without surface groove and an autograft were also conducted in the same test. The electrophysiological, walking track, gastrocnemius muscle, triple-immunofluorescence, and immunohistological analyses indicated that grooved fibers effectively improved sciatic nerve regeneration. This is mainly attributed to the highly ordered secondary structure formed by surface grooves and an increase in the specific surface area. Fibrous conduits made of longitudinally aligned nanofibers with longitudinal nanogrooves on the fiber surface may offer a new nerve guidance conduit for peripheral nerve repair and regeneration.
- Subjects :
- Male
Materials science
Surface Properties
Nanofibers
Nerve guidance conduit
Nanotechnology
Rats, Sprague-Dawley
Tissue engineering
Materials Testing
medicine
Animals
General Materials Science
Fiber
Tissue Scaffolds
Guided Tissue Regeneration
Regeneration (biology)
Equipment Design
Sciatic nerve injury
medicine.disease
Electrospinning
Nerve Regeneration
Rats
Equipment Failure Analysis
Treatment Outcome
Nanofiber
Sciatic nerve
Sciatic Neuropathy
Biomedical engineering
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....0f0a547c7da4f5ecd0b5706c1a1560c7