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Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis
- Source :
- ERJ Open Research, article-version (VoR) Version of Record, ERJ Open Research, Vol 6, Iss 3 (2020)
- Publication Year :
- 2020
- Publisher :
- European Respiratory Society (ERS), 2020.
-
Abstract
- Background Mucus dehydration and impaired mucus clearance are common features of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). In CF, inhaled hypertonic saline (HS) improves lung function and produces sustained increases in mucociliary clearance (MCC). We hypothesised that administration of HS (7% NaCl) twice daily for 2 weeks would improve clinical outcomes and produce sustained increases in MCC in COPD subjects with a chronic bronchitis (CB) phenotype. Methods Twenty-two CB subjects completed a double-blinded, crossover study comparing inhaled HS to a hypotonic control solution (0.12% saline) administered via nebuliser twice daily for 2 weeks. Treatment order was randomised. During each treatment period, symptoms and spirometry were measured. MCC was measured at baseline, shortly after initial study agent administration, and approximately 12 h after the final dose. Results HS was safe and well tolerated but overall produced no significant improvements in spirometry or patient-reported outcomes. CB subjects had slower baseline MCC than healthy subjects. The MCC rates over 60 min (Ave60Clr) in CB subjects following 2 weeks of HS were not different from 0.12% saline but were slower than baseline (Ave60Clr was 9.1±6.3% at baseline versus 5.3±6.9% after HS; p<br />2-week HS treatment in CB does not lead to overall improvement in baseline mucociliary clearance. However, a subgroup of patients with residual, noncough-induced central airway clearance does show improvement in both spirometry and symptoms. https://bit.ly/36ji6Vn
- Subjects :
- Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_specialty
Chronic bronchitis
Mucociliary clearance
medicine.medical_treatment
Population
lcsh:Medicine
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
COPD
education
Saline
education.field_of_study
medicine.diagnostic_test
business.industry
lcsh:R
Original Articles
medicine.disease
Crossover study
Hypertonic saline
030228 respiratory system
business
Subjects
Details
- ISSN :
- 23120541
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- ERJ Open Research
- Accession number :
- edsair.doi.dedup.....0ef9ea188e35b75faab0398ff9741bfe