Back to Search
Start Over
Tamsulosin does not increase 1-week passage rate of ureteral stones in ED patients
- Source :
- The American Journal of Emergency Medicine. 33:1721-1724
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Objective The objective of the study is to determine if tamsulosin initiated in the emergency department (ED) decreases the time to ureteral stone passage at 1 week or time to pain resolution, compared to placebo. Methods We performed a prospective, randomized, double-blinded, placebo-controlled trial of tamsulosin vs placebo in ED patients with ureterolithiasis on computed tomography. Patients were identified and enrolled between April 2007 and February 2009 and were randomized to either 0.4 mg of tamsulosin or placebo for 1 week. We contacted participants using a telephone survey on post-ED visit days 1, 2, 3, and 7. The primary outcome was time to stone passage, with secondary outcomes being maximum pain score and amount of pain medication required. Results Of the 127 patients enrolled during this study, 15 were lost to follow-up, and 12 required surgical interventions before the 7-day mark, leaving 100 patients for analysis. Of the 100 patients, 53 received tamsulosin and 47 received placebo. There was no difference between groups in percentage of male, mean age, initial serum creatinine, average stone size, stone location, and history of prior stone. The probability that the patient did not pass a stone at 7 days was not different between tamsulosin and placebo, 62.1% (95% confidence interval, 49.1%-75.1%) vs 54.4% (95% confidence interval, 40.3%-68.6%; P = .58). There was no significant difference in the high pain score ( P = .12) or hydrocodone/acetaminophen intake ( P = .76) between treatment groups at any of the time points. Conclusion This study reveals no difference in the proportion of stone passage or high pain score and pain medication utilization at 7 days between tamsulosin and placebo.
- Subjects :
- Adult
Male
Tamsulosin
Time Factors
Ureteral Calculi
Pain
Placebo
law.invention
Double-Blind Method
Randomized controlled trial
law
medicine
Humans
Prospective Studies
Prospective cohort study
Analgesics
Sulfonamides
business.industry
General Medicine
Emergency department
Confidence interval
Acetaminophen
Treatment Outcome
Hydrocodone
Anesthesia
Adrenergic alpha-1 Receptor Antagonists
Emergency Medicine
Female
Emergency Service, Hospital
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 07356757
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- The American Journal of Emergency Medicine
- Accession number :
- edsair.doi.dedup.....0eed5a6e0b6bf65cf08e933592bbe2af