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Prognostic impact of Ki-67 in patients with gastric cancer—the importance of depth of invasion and histologic differentiation

Authors :
Se-Il Go
Soon-Chan Hong
Jeong-Hee Lee
Won Sup Lee
Woo Song Ha
Sang-Ho Jeong
Young-Joon Lee
Gyung Hyuck Ko
Source :
Medicine
Publication Year :
2017
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2017.

Abstract

Supplemental Digital Content is available in the text<br />Ki-67 protein is a cellular marker for proliferation. The role of Ki-67 as a prognostic biomarker has not been established in gastric cancer. The present study was performed to investigate the significance of Ki-67 expression as a biomarker in early gastric cancer (EGC). With tissue microarray for 320 patients with gastric cancer, we performed immunohistochemical staining for Ki-67. Its clinical significance was analyzed with adjustment via the propensity score-matching. For validation, we performed bootstrap resampling. The median follow-up duration was 72 months (range: 3–120 months). Ki-67-high group showed worse prognosis than Ki-67-low group in EGC (5-YSR, 78.9% vs 92.0%, P = .018), but not in advanced gastric cancer (AGC) (5-YSR, 58.5% vs 59.2%, P = .951). Interestingly, in the patients with well-differentiated histology, prognosis for Ki-67-high group was considerably worse than that for Ki-67-low group (5-YSR, 67.0% vs 94.4%, P = .012), but not in those with moderately differentiated (P = .504) and poorly differentiated histology (P = .905). In this cohort, there was a strong correlation between the proportion of EGC and well-differentiated histology (r = 0.215, P = .002). Multivariate analysis also revealed that the high-Ki-67 expression serves as a poor prognostic factor in EGC (HR 4.346, 95% CI 1.397–13.515, P = .011), especially in the well-differentiated histology, but not in all the patients (P = .171). Bootstrap resampling internally validated this result (P = .011). This study suggests that Ki-67 expression may be a good biomarker for prognosis prediction for EGC with well-differentiated histologic type.

Details

ISSN :
00257974
Volume :
96
Database :
OpenAIRE
Journal :
Medicine
Accession number :
edsair.doi.dedup.....0ee20acaa4815f12f88531ee467288d8
Full Text :
https://doi.org/10.1097/md.0000000000007181