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Adenosine: An endogenous mediator in the pathogenesis of gynecological cancer
- Source :
- Journal of Cellular Physiology. 233:2715-2722
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Extracellular concentration of adenosine increases in the hypoxic tumor microenvironment. Adenosine signaling regulates apoptosis, angiogenesis, metastasis, and immune suppression in cancer cells. Adenosine-induced cell responses depend upon different subtypes of adenosine receptors activation and type of cancer. Suppression of adenosine signaling via inhibition of adenosine receptors or adenosine generating enzymes including CD39 and CD73 on ovarian or cervical cancer cells is a potentially novel therapeutic approach for gynecological cancer patients. This review summarizes the role of adenosine in the pathogenesis of gynecological cancer for a better understanding and hence a better management of this disease.
- Subjects :
- 0301 basic medicine
Adenosine
Genital Neoplasms, Female
Physiology
Clinical Biochemistry
Models, Biological
Metastasis
03 medical and health sciences
0302 clinical medicine
Animals
Humans
Medicine
business.industry
Cancer
Cell Biology
Purinergic signalling
medicine.disease
Adenosine A3 receptor
Adenosine receptor
030104 developmental biology
030220 oncology & carcinogenesis
Cancer cell
Immunology
Cancer research
Female
Signal transduction
business
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 00219541
- Volume :
- 233
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi.dedup.....0edd403d0fba424f42fe4f4bb7d6e5c9