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Precuneus abnormalities in middle-aged to older adults with depressive symptoms: An analysis of BDI-II symptom dimensions
- Source :
- Psychiatry Research: Neuroimaging. 268:9-14
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- We recently reported age-related increases in left precuneus cortical thickness (CT) in older adults with elevated total depressive symptoms. However, it is unclear whether abnormalities in precuneus surface area (SA) are also evident and whether specific symptom dimensions of depression moderated age effects on these measurements. Seventy-three adults completed the Beck Depression Inventory - 2nd edition (BDI-II) and underwent structural neuroimaging. Measures of CT and SA were extracted from the right and left precuneus via FreeSurfer. Regression models included regions of interest as dependent variables, with age, BDI-II subscale scores (e.g., affective, cognitive, and somatic symptoms), and their interactions as independent variables, controlling for mean hemispheric thickness (for CT) or total intracranial volume (for SA). A significant age × somatic symptom interaction was found for left precuneus CT, such that elevated levels of somatic symptoms were significantly associated with age-related cortical thinning. No depressive symptom dimensions moderated the relationship between age and SA, suggesting that CT may be a more sensitive measure of brain abnormalities in middle-aged to older adults with depressive symptoms.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neuroscience (miscellaneous)
Precuneus
Neuroimaging
Article
03 medical and health sciences
0302 clinical medicine
Parietal Lobe
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Psychiatry
Depression (differential diagnoses)
Depressive symptoms
Aged
Aged, 80 and over
Cerebral Cortex
Psychiatric Status Rating Scales
Brain Diseases
030214 geriatrics
Depression
Age Factors
Parietal lobe
Beck Depression Inventory
Regression analysis
Cognition
Middle Aged
Psychiatry and Mental health
medicine.anatomical_structure
Regression Analysis
Female
Psychology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09254927
- Volume :
- 268
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research: Neuroimaging
- Accession number :
- edsair.doi.dedup.....0edc7e9f6ee9f3f205f84837cf3eb970