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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
- Publication Year :
- 2016
-
Abstract
- Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10(-9)), particularly in younger women (
- Subjects :
- Oncology
medicine.medical_specialty
Genotype
medicine.drug_class
European Continental Ancestry Group
Estrogen receptor
Locus (genetics)
Genome-wide association study
Breast Neoplasms
Biology
Polymorphism, Single Nucleotide
White People
Article
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Breast cancer
Internal medicine
Receptors
medicine
Genetics
Humans
Genetic Predisposition to Disease
Allele
Polymorphism
Telomerase
030304 developmental biology
Aged
African Americans
0303 health sciences
Case-Control Studies
Female
Genome-Wide Association Study
Membrane Proteins
Middle Aged
Neoplasm Proteins
Receptors, Estrogen
Genetic Loci
Single Nucleotide
medicine.disease
Estrogen
3. Good health
Black or African American
030220 oncology & carcinogenesis
Immunology
Subjects
Details
- Language :
- English
- ISSN :
- 10069690
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0edb8a684f99bc7d7bab8eebda278e89