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A randomised controlled intervention study investigating the efficacy of carotenoid-rich fruits and vegetables and extra-virgin olive oil on attenuating sarcopenic symptomology in overweight and obese older adults during energy intake restriction: protocol paper
- Source :
- BMC Geriatrics, BMC Geriatrics, Vol 18, Iss 1, Pp 1-10 (2018)
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background Weight loss interventions have not been advocated for overweight/obese older adults due to potential loss of skeletal muscle and strength impacting on physical function with potential loss of independence. Carotenoids and polyphenols are inversely associated with sarcopenic symptomology. This paper reports the protocol of a study evaluating the efficacy of a high-protein, energy restricted diet rich in carotenoids and polyphenols on body composition, muscle strength, physical performance and quality of life in overweight and obese older adults. Methods This randomised controlled clinical trial will recruit community-dwelling, healthy overweight and obese older adults (≥60 years) for a 12-week weight loss intervention. Seventy-three participants will be recruited and randomized to an energy restricted (~30% restriction), isocaloric diet (30% protein; 30% carbohydrate; 40% fat) enriched with either: a) 375 g/d of high carotenoid vegetables, 300 g/d high carotenoid fruit, and 40-60 ml extra-virgin olive oil (EVOO); or b) 375 g/d of lower carotenoid vegetables, 300 g/d lower carotenoid fruit, and 40-60 ml Polyunsaturated fatty acid (PUFA) based oil. All participants will receive individual dietary counselling each fortnight for the duration of the study and will be asked to maintain their habitual level of physical activity throughout the study. The primary outcome will be appendicular skeletal muscle (ASM) assessed by dual energy X-ray absorptiometry (DXA). Secondary outcomes will include body weight, fat-free mass (FFM), fat mass (FM), muscle strength (Isometric hand-grip strength), physical performance (Short Physical Performance Battery), physical activity (International Physical Activity Questionnaire) and health related quality of life (SF-36). Outcomes will be measured at baseline and at week 12. Discussion The results of this study will provide a novel insight relating to the potential influence of high carotenoid and polyphenol intakes on attenuation of ASM during dietary energy-restricted weight loss in overweight and obese older adults. Trial registration The trial was registered on the Australia New Zealand Clinical Trials Register ( ACTRN12616001400459 ); Trial registration date: 10th October, 2016.
- Subjects :
- Male
0301 basic medicine
obesity
Weight loss
Sarcopenia
Extra-virgin olive oil
Isometric exercise
lcsh:Geriatrics
Overweight
Study Protocol
0302 clinical medicine
Quality of life
fruit and vegetables
Vegetables
030212 general & internal medicine
Carotenoid
older adults
chemistry.chemical_classification
carotenoids
food and beverages
Middle Aged
Treatment Outcome
Older adults
Female
Nutrition Therapy
medicine.symptom
Polyunsaturated fatty acid
medicine.medical_specialty
03 medical and health sciences
Internal medicine
medicine
Humans
Obesity
extra-virgin olive oil
Exercise
Olive Oil
polyphenols
Aged
Caloric Restriction
030109 nutrition & dietetics
business.industry
Polyphenols
medicine.disease
Carotenoids
Clinical trial
lcsh:RC952-954.6
chemistry
Fruit
Quality of Life
weight loss
Fruit and vegetables
Geriatrics and Gerontology
Energy Intake
business
Subjects
Details
- ISSN :
- 14712318 and 12616001
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Geriatrics
- Accession number :
- edsair.doi.dedup.....0ed2e1791206c9fe32640c4582193300