Additional file 4 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

Additional file 4: Figure S4. Tamoxifen-induced reduction of astrocytic APOE4 in cortical regions with and without CAA/plaques. a, Representative images of X34 for amyloid plaques/CAA, APOE, GFAP+ astrocytes, and IBA1+ microglia. Arrowhead: APOE in astrocyte. Arrow: APOE in microglia. Scalebar: 50 µm. b, Percentage of APOE coverage in cortical regions with CAA, plaques, or without CAA/plaques. c, d, Ratio of APOE in GFAP+ astrocytes (c) or IBA1+ (d) microglia area coverage normalized to CAA/plaque load. ∆ = males, ○ = females. Data expressed as mean ± SEM, student’s t-test (two-sided) performed for all statistical analyses except (b – no plaques, CAA, plaques), (c – no plaques, CAA, plaques), and (d – no plaques, CAA), where Welch’s t-test was performed. *P < 0.05, **P < 0.01. No other statistical comparisons are significant unless indicated.