Back to Search
Start Over
Inflammatory bowel disease course in liver transplant versus non-liver transplant patients for primary sclerosing cholangitis: LIVIBD, an IG-IBD study
- Source :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 53(6)
- Publication Year :
- 2020
-
Abstract
- Background Data regarding the effect of orthotopic liver transplantation (OLT) for primary sclerosing cholangitis (PSC) on inflammatory bowel disease (IBD) course are scarce and conflicting. Aims To compare the incidence of refractory IBD in two groups (OLT and non-OLT) of patients affected by IBD and PSC. Methods An observational, multicentre, cohort retrospective study was conducted by the Italian Group for the study of IBD in Italy. The primary outcome was the need for biologic therapy or bowel resection for medically refractory IBD or hospitalization due to IBD relapse during the follow-up. Secondary outcomes were rate of colonic dysplasia, colorectal cancer, other solid tumours, lymphoma. Results Eighty-four patients were included in the study. The primary outcome was not different between OLT and non-OLT groups (11/27, 40.7%, versus 20/57, 35.1%, respectively, p = 0.62). The lymphoma and other tumours (thyroid cancer, kidney cancer, ileal tumour, ovarian cancer, cervical cancer) rates were significantly higher in the OLT group (p = 0.04 and p = 0.005, respectively), at the limit of statistical significance for high-grade colonic dysplasia (p = 0.06). Conclusion OLT in patients affected by IBD and PSC is not a risk factor for a more severe IBD course, but it is associated with a higher occurrence of cancer.
- Subjects :
- Adult
Male
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
Cholangitis, Sclerosing
OLT
Kaplan-Meier Estimate
digestive system
Gastroenterology
Inflammatory bowel disease
Primary sclerosing cholangitis
03 medical and health sciences
0302 clinical medicine
PSC
Risk Factors
Internal medicine
medicine
Humans
Orthotopic liver transplantation
Retrospective Studies
Cervical cancer
Hepatology
business.industry
Cancer
Retrospective cohort study
Bowel resection
Middle Aged
medicine.disease
Inflammatory Bowel Diseases
digestive system diseases
Liver Transplantation
surgical procedures, operative
Italy
030220 oncology & carcinogenesis
Disease Progression
030211 gastroenterology & hepatology
Female
business
Kidney cancer
Subjects
Details
- ISSN :
- 18783562
- Volume :
- 53
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Accession number :
- edsair.doi.dedup.....0ebf0183894761f1907465a07b74b686