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Antigenic and molecular characterisation of Border disease virus associated with high mortality in lambs in Spain

Antigenic and molecular characterisation of Border disease virus associated with high mortality in lambs in Spain

Authors :
T. Pérez
José A. Orden
R. de la Fuente
Oscar Cabezón
Ignasi Marco
Santiago Vega
S. González
Clara Marin
Rafael Rosell
Source :
Veterinary Record Open, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Introduction Border disease virus (BDV) causes congenital disorders in sheep and results in severe, but underestimated, economic losses worldwide. However, information about BDV strains affecting several ruminants worldwide is scarce. Therefore, antigenic and genetic classification of isolates from different geographical regions is important to enhance the knowledge of the epidemiology of BDV. Materials and methods Five pestiviruses isolated from lambs in an epidemic outbreak with an unusually high mortality in Spain in 1997 were characterised antigenically with a panel of monoclonal antibodies and genetically by sequencing within the 50 untranslated (50UTR) region of the genome. Results All the isolates were classified as BDV and showed a high homology with the Aveyron strain (Av), which was associated with an epidemic reported in sheep from the Aveyron region of France in 1984. Conclusions Classification of the isolates from this study provides valuable information on the molecular epidemiology of BDV.

Details

ISSN :
20526113 and 23992050
Volume :
2
Database :
OpenAIRE
Journal :
Veterinary Record Open
Accession number :
edsair.doi.dedup.....0eb0d2dae6795c23eda8b178d12dcfd5
Full Text :
https://doi.org/10.1136/vetreco-2014-000048