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Room-Temperature and Transition-Metal-Free Intramolecular α-Arylation of Ketones: A Mild Access to Tetracyclic Indoles and 7-Azaindoles
- Source :
- Organic Letters, Organic Letters, American Chemical Society, 2018, 21 (1), pp.320-324. ⟨10.1021/acs.orglett.8b03831⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- A novel approach for the synthesis of tetracyclic indoles and 7-azaindoles is reported. The strategy involves four steps, with a fast rt intramolecular α-arylation of ketones as key step. The reaction was inspected synthetically to achieve the synthesis of 11 novel tetracyclic structures with moderate to very good yields (39-85%). Theoretical combined with experimental studies led us to propose a probable polar mechanism (concerted S
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Database :
- OpenAIRE
- Journal :
- Organic Letters, Organic Letters, American Chemical Society, 2018, 21 (1), pp.320-324. ⟨10.1021/acs.orglett.8b03831⟩
- Accession number :
- edsair.doi.dedup.....0ea8655a80ea29bffb05a11e1ce43bd0
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b03831⟩