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Silver and nanoparticles of silver in wound dressings: a review of efficacy and safety
- Source :
- Journal of Wound Care. 20:543-549
- Publication Year :
- 2011
- Publisher :
- Mark Allen Group, 2011.
-
Abstract
- Wound infections present a significant clinical challenge, impacting on patient morbidity and mortality, with significant economic implications. Silver-impregnated wound dressings have the potential to reduce both wound bioburden and healing time. The silver ion Ag+ is the active antimicrobial entity; it can interfere with thiol (−SH) groups and provoke the generation of reactive oxygen species (ROS), a major contributor to its antibacterial efficacy. Recently, silver nanoparticles have gained considerable interest in wound bioburden reduction and in anti-inflammation, as they can release Ag+ ions at a greater rate than bulk silver, by virtue of their large surface area. If released from dressings, they also have the potential to cross biological compartments. This review aims to consolidate recent findings as to the efficacy and safety of different formulations of silver used as an antiseptic agent in dressings, summarising the features of silver nanomaterials, with particular attention to the dose-dependencies for biological effects, highlighting the need for information on their uptake and potential biological effects.
- Subjects :
- medicine.medical_specialty
Silver
Nursing (miscellaneous)
integumentary system
business.industry
Metal Nanoparticles
Nanoparticle
Healing time
Antiseptic Agent
Silver ion
Antibacterial efficacy
Pharmacology
Antimicrobial
Bandages
Silver nanoparticle
Surgery
Bioburden
Anti-Infective Agents, Local
medicine
Humans
Wounds and Injuries
Fundamentals and skills
Safety
business
Subjects
Details
- ISSN :
- 20522916 and 09690700
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of Wound Care
- Accession number :
- edsair.doi.dedup.....0ea3ec7ab0219a27d8ebe2ce314adf88