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Structure, mechanism, and regulation of mitochondrial DNA transcription initiation
- Source :
- The Journal of Biological Chemistry
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Mitochondria are specialized compartments that produce requisite ATP to fuel cellular functions and serve as centers of metabolite processing, cellular signaling, and apoptosis. To accomplish these roles, mitochondria rely on the genetic information in their small genome (mitochondrial DNA) and the nucleus. A growing appreciation for mitochondria's role in a myriad of human diseases, including inherited genetic disorders, degenerative diseases, inflammation, and cancer, has fueled the study of biochemical mechanisms that control mitochondrial function. The mitochondrial transcriptional machinery is different from nuclear machinery. The in vitro re-constituted transcriptional complexes of Saccharomyces cerevisiae (yeast) and humans, aided with high-resolution structures and biochemical characterizations, have provided a deeper understanding of the mechanism and regulation of mitochondrial DNA transcription. In this review, we will discuss recent advances in the structure and mechanism of mitochondrial transcription initiation. We will follow up with recent discoveries and formative findings regarding the regulatory events that control mitochondrial DNA transcription, focusing on those involved in cross-talk between the mitochondria and nucleus. ispartof: JOURNAL OF BIOLOGICAL CHEMISTRY vol:295 issue:52 pages:18406-18425 ispartof: location:United States status: published
- Subjects :
- 0301 basic medicine
Mitochondrial DNA
Cell signaling
Transcription, Genetic
DNA transcription
Mitochondrion
Biology
DNA, Mitochondrial
mitochondrial DNA transcription
Biochemistry
Genome
structure-function
Mitochondrial Proteins
03 medical and health sciences
chemistry.chemical_compound
Transcription (biology)
RNA polymerase
Transcriptional regulation
Humans
enzyme mechanism
Molecular Biology
human mitochondrial RNA polymerase
030102 biochemistry & molecular biology
JBC Reviews
transcription initiation factors
Cell Biology
mitochondrial DNA (mtDNA)
Enzyme structure
enzyme structure
Cell biology
mitochondria
030104 developmental biology
Gene Expression Regulation
chemistry
mitochondrial gene regulation
Transcription Initiation Site
transcription
transcription regulation
Transcription Factors
yeast mitochondrial RNA polymerase
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 295
- Database :
- OpenAIRE
- Journal :
- Journal of Biological Chemistry
- Accession number :
- edsair.doi.dedup.....0ea276b8136530df92ac97d917d5a6a0