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Can daclizumab reduce acute rejection and improve long-term renal function in tacrolimus-based primary renal transplant recipients?
- Source :
- Nephrology. 13:251-255
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- SUMMARY: Aims: To evaluate the efficacy and safety of a tacrolimus-based immunosuppressive regimen with and without induction therapy using daclizumab in first cadaveric renal transplant recipients. Methods: Since January 2001, we studied the effect of daclizumab in a non-randomized and prospective study of 36 sequential first cadaveric renal transplant recipients. They were compared with a historical control group of 21 sequential first cadaveric renal transplant recipients without induction therapy. All patients received tacrolimus, azathioprine and corticosteroids as concomitant immunosuppressive therapy. Daclizumab was given at 1 mg/kg infusion 2 h before transplantation and then every 14 days for four more doses. Outcomes measured included incidence of acute rejection, patient survival, graft survival, annualized change in creatinine clearance (CrCl), cardiovascular risk profile, infection and malignancy. Results: Fewer biopsy proven acute rejections were observed in the induction treatment group: 11.1% (4/36) versus 19% (4/21) but the rejection free survival was similar (P = 0.37). The patient survival and graft survival were comparable. The renal function was similar in both groups. There were also no significant difference in infection, malignancy and cardiovascular risk profile in both groups. Conclusion: Adding daclizumab to a tacrolimus-based therapy is safe but cannot further improve clinical efficacy.
- Subjects :
- Adult
Graft Rejection
Male
medicine.medical_specialty
Daclizumab
Time Factors
Urology
Renal function
Azathioprine
Opportunistic Infections
Antibodies, Monoclonal, Humanized
Kidney
Tacrolimus
Adrenal Cortex Hormones
Neoplasms
medicine
Humans
Prospective Studies
Intensive care medicine
Prospective cohort study
Kidney transplantation
business.industry
Antibodies, Monoclonal
General Medicine
Middle Aged
medicine.disease
Kidney Transplantation
Transplantation
Treatment Outcome
surgical procedures, operative
Cardiovascular Diseases
Nephrology
Creatinine
Immunoglobulin G
Concomitant
Acute Disease
Drug Therapy, Combination
Female
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 14401797 and 13205358
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nephrology
- Accession number :
- edsair.doi.dedup.....0ea0dc452d464009b6809d2bde2bd0e7