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Parotid gland fat related Magnetic Resonance image biomarkers improve prediction of late radiation-induced xerostomia
- Source :
- Radiotherapy and Oncology, 128(3), 459-466. ELSEVIER IRELAND LTD
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Purpose: This study investigated whether Magnetic Resonance image biomarkers (MR-IBMs) were associated with xerostomia 12 months after radiotherapy (Xer(12m)) and to test the hypothesis that the ratio of fat-to-functional parotid tissue is related to Xer(12m). Additionally, improvement of the reference Xer(12m) model based on parotid gland dose and baseline xerostomia, with MR-IBMs was explored.Methods: Parotid gland MR-IBMs of 68 head and neck cancer patients were extracted from pre-treatment T1-weighted MR images, which were normalized to fat tissue, quantifying 21 intensity and 43 texture image characteristics. The performance of the resulting multivariable logistic regression models after bootstrapped forward selection was compared with that of the logistic regression reference model. Validity was tested in a small external cohort of 25 head and neck cancer patients.Results: High intensity MR-IBM P90 (the 90th intensity percentile) values were significantly associated with a higher risk of Xer(12m). High P90 values were related to high fat concentration in the parotid glands. The MR-IBM P90 significantly improved model performance in predicting Xer(12m) (likelihood-ratio-test; p = 0.002), with an increase in internally validated AUC from 0.78 (reference model) to 0.83 (P90). The MR-IBM P90 model also outperformed the reference model (AUC = 0.65) on the external validation cohort (AUC = 0.83).Conclusion: Pre-treatment MR-IBMs were associated to radiation-induced xerostomia, which supported the hypothesis that the amount of predisposed fat within the parotid glands is associated with Xer(12m). In addition, xerostomia prediction was improved with MR-IBMs compared to the reference model. (C) 2018 The Authors. Published by Elsevier B.V.
- Subjects :
- Male
Percentile
medicine.medical_treatment
NTCP
Logistic regression
STICKY SALIVA
030218 nuclear medicine & medical imaging
0302 clinical medicine
Parotid Gland
Head and neck cancer
Image biomarkers
SJOGRENS-SYNDROME
medicine.diagnostic_test
Radiotherapy Dosage
Hematology
Middle Aged
Prognosis
Magnetic Resonance Imaging
F-18-FDG PET/CT
Parotid gland
PROGNOSTIC VALUE
medicine.anatomical_structure
Adipose Tissue
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Predictive value of tests
Female
SQUAMOUS-CELL CARCINOMA
Adult
NECK-CANCER-PATIENTS
Adolescent
SALIVARY-GLANDS
Radiation Dosage
Xerostomia
Article
Young Adult
03 medical and health sciences
stomatognathic system
Predictive Value of Tests
TEXTURE ANALYSIS
medicine
Humans
Radiology, Nuclear Medicine and imaging
HEAD
Radiation Injuries
Radiometry
Aged
Radiomics
business.industry
Magnetic resonance imaging
medicine.disease
Intensity (physics)
INTENSITY-MODULATED RADIOTHERAPY
Radiation therapy
Logistic Models
Radiotherapy, Intensity-Modulated
Radiotherapy, Conformal
business
Nuclear medicine
Biomarkers
Subjects
Details
- ISSN :
- 01678140
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and Oncology
- Accession number :
- edsair.doi.dedup.....0e8a770efb1c80ea772456cffe451a1e