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Decreased number of vasopressin immunoreactive neurons in the medial amygdala and locus coeruleus of the aged rat
- Source :
- Neurobiology of Aging, 14, 245-248. Elsevier B.V.
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- The earlier described age-related decreases in vasopressin innervation of extra-hypothalamic rat brain regions were found to coincide with a decrease in vasopressin expression in the cells where these fibers originated. A significant age-related decrease in the number of vasopressin-immunoreactive cell bodies was found in the medial amygdala and locus coeruleus of senescent Brown-Norway (BN/BiRij) rats (33 months) when compared to middle-aged (19 months) and young (3 months) rats. In addition, total testosterone plasma levels were significantly reduced in middle-aged and old rats as compared to young animals and the number of vasopressin-immunoreactive cells in both the medial amygdala and locus coeruleus correlated significantly with the decreased testosterone levels in a similar way as found earlier for vasopressin terminals.
- Subjects :
- Male
Senescence
Aging
medicine.medical_specialty
Vasopressin
Vasopressins
Central nervous system
Immunocytochemistry
Neuropeptide
Biology
Amygdala
Rats, Inbred BN
Internal medicine
medicine
Animals
Testosterone
Neurons
Sex Characteristics
General Neuroscience
Immunohistochemistry
Rats
Endocrinology
medicine.anatomical_structure
Locus coeruleus
Locus Coeruleus
Neurology (clinical)
Geriatrics and Gerontology
hormones, hormone substitutes, and hormone antagonists
Developmental Biology
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....0e72d3f95b7d98a2c63b41592624c1e3