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Maternal hypercholesterolemia in pregnancy associates with umbilical vein endothelial dysfunction: role of endothelial nitric oxide synthase and arginase II
- Source :
- ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, Artículos CONICYT, CONICYT Chile, instacron:CONICYT
- Publication Year :
- 2013
-
Abstract
- Objective— Human pregnancy that courses with maternal supraphysiological hypercholesterolemia (MSPH) correlates with atherosclerotic lesions in fetal arteries. It is known that hypercholesterolemia associates with endothelial dysfunction in adults, a phenomenon where nitric oxide (NO) and arginase are involved. However, nothing is reported on potential alterations in the fetoplacental endothelial function in MSPH. The aim of this study was to determine whether MSPH alters fetal vascular reactivity via endothelial arginase/urea and l -arginine transport/NO signaling pathways. Approach and Results— Total cholesterol l -citrulline synthesis from l -arginine, eNOS phosphorylation/dephosphorylation), but increased arginase activity and arginase II protein abundance. Arginase inhibition increased eNOS activity and l -arginine transport capacity without altering human cationic amino acid transporter 1 or human cationic amino acid transporter 2A/B protein abundance in maternal physiological hypercholesterolemia and MSPH. Conclusions— MSPH is a pathophysiological condition altering umbilical vein reactivity because of fetal endothelial dysfunction associated with arginase and eNOS signaling imbalance. We speculate that elevated maternal circulating cholesterol is a factor leading to fetal endothelial dysfunction, which could have serious consequences to the growing fetus.
- Subjects :
- Adult
medicine.medical_specialty
Umbilical Veins
Endothelium
Nitric Oxide Synthase Type III
Hypercholesterolemia
Biology
Nitric Oxide
Umbilical vein
Nitric oxide
chemistry.chemical_compound
Young Adult
Pregnancy
Internal medicine
medicine
Human Umbilical Vein Endothelial Cells
Humans
Urea
Endothelial dysfunction
Cationic Amino Acid Transporter 2
Cells, Cultured
Cationic Amino Acid Transporter 1
Fetus
Electrical impedance myography
Arginase
medicine.disease
Lipids
Pregnancy Complications
Kinetics
Endocrinology
medicine.anatomical_structure
chemistry
Female
Pregnancy Trimesters
Cardiology and Cardiovascular Medicine
Signal Transduction
Subjects
Details
- ISSN :
- 15244636
- Volume :
- 33
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Accession number :
- edsair.doi.dedup.....0e6791d3bea9ab028c81fd7d89b0d5f1