Back to Search
Start Over
Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence
- Source :
- Jones, H J, Hammerton, G L, McCloud, T, Hines, L A, Wright, C L, Gage, S H, Holmans, P, Jones, P, Davey Smith, G, Linden, D E, O'Donovan, M C, Owen, M J, Walters, J T, Munafò, M R, Heron, J E & Zammit, S 2020, ' Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence ', Psychological Medicine . https://doi.org/10.1017/S0033291720001798, PSYCHOLOGICAL MEDICINE
- Publication Year :
- 2020
- Publisher :
- Cambridge University Press (CUP), 2020.
-
Abstract
- BackgroundIt is not clear to what extent associations between schizophrenia, cannabis use and cigarette use are due to a shared genetic etiology. We, therefore, examined whether schizophrenia genetic risk associates with longitudinal patterns of cigarette and cannabis use in adolescence and mediating pathways for any association to inform potential reduction strategies.MethodsAssociations between schizophrenia polygenic scores and longitudinal latent classes of cigarette and cannabis use from ages 14 to 19 years were investigated in up to 3925 individuals in the Avon Longitudinal Study of Parents and Children. Mediation models were estimated to assess the potential mediating effects of a range of cognitive, emotional, and behavioral phenotypes.ResultsThe schizophrenia polygenic score, based on single nucleotide polymorphisms meeting a training-set p threshold of 0.05, was associated with late-onset cannabis use (OR = 1.23; 95% CI = 1.08,1.41), but not with cigarette or early-onset cannabis use classes. This association was not mediated through lower IQ, victimization, emotional difficulties, antisocial behavior, impulsivity, or poorer social relationships during childhood. Sensitivity analyses adjusting for genetic liability to cannabis or cigarette use, using polygenic scores excluding the CHRNA5-A3-B4 gene cluster, or basing scores on a 0.5 training-set p threshold, provided results consistent with our main analyses.ConclusionsOur study provides evidence that genetic risk for schizophrenia is associated with patterns of cannabis use during adolescence. Investigation of pathways other than the cognitive, emotional, and behavioral phenotypes examined here is required to identify modifiable targets to reduce the public health burden of cannabis use in the population.
- Subjects :
- Mediation (statistics)
Longitudinal study
cannabis-use
Population
Single-nucleotide polymorphism
Impulsivity
03 medical and health sciences
0302 clinical medicine
Risk Factors
Tobacco
Medicine
polygenic score
mediation
Genetic Predisposition to Disease
Longitudinal Studies
education
health care economics and organizations
Applied Psychology
Cannabis
education.field_of_study
biology
business.industry
Tobacco and Alcohol
Cognition
Tobacco Products
ALSPAC
medicine.disease
biology.organism_classification
030227 psychiatry
schizophrenia
Psychiatry and Mental health
Schizophrenia
Physical and Mental Health
cigarette-use
medicine.symptom
business
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- ISSN :
- 14698978 and 00332917
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Psychological Medicine
- Accession number :
- edsair.doi.dedup.....0e65f472a6360695fabaaa1495e48453