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Limitations of Gene Duplication Models: Evolution of Modules in Protein Interaction Networks
- Source :
- Emmert-Streib, F 2012, ' Limitations of Gene Duplication Models: Evolution of Modules in Protein Interaction Networks ', PLoS ONE, vol. 7, no. 4, e35531, pp. 1-13 . https://doi.org/10.1371/journal.pone.0035531, PLoS ONE, PLoS ONE, Vol 7, Iss 4, p e35531 (2012)
- Publication Year :
- 2012
-
Abstract
- It has been generally acknowledged that the module structure of protein interaction networks plays a crucial role with respect to the functional understanding of these networks. In this paper, we study evolutionary aspects of the module structure of protein interaction networks, which forms a mesoscopic level of description with respect to the architectural principles of networks. The purpose of this paper is to investigate limitations of well known gene duplication models by showing that these models are lacking crucial structural features present in protein interaction networks on a mesoscopic scale. This observation reveals our incomplete understanding of the structural evolution of protein networks on the module level. © 2012 Emmert-Streib.
- Subjects :
- Proteomics
Evolutionary Processes
Proteome
Science
Computational biology
Biology
Architectural principles
Biochemistry
Evolution, Molecular
Gene Duplication
Gene duplication
Cluster Analysis
Protein Interaction Maps
Statistical Methods
Protein Interactions
Genetics
Structure (mathematical logic)
Medicine(all)
Evolutionary Biology
Mesoscopic physics
Multidisciplinary
Models, Genetic
Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Systems Biology
Quantitative Biology::Molecular Networks
Statistics
Proteins
Computational Biology
Genomic Evolution
Structural evolution
Protein Interaction Networks
Medicine
Protein network
Algorithms
Mathematics
Protein Interaction Map
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Emmert-Streib, F 2012, ' Limitations of Gene Duplication Models: Evolution of Modules in Protein Interaction Networks ', PLoS ONE, vol. 7, no. 4, e35531, pp. 1-13 . https://doi.org/10.1371/journal.pone.0035531, PLoS ONE, PLoS ONE, Vol 7, Iss 4, p e35531 (2012)
- Accession number :
- edsair.doi.dedup.....0e5c27d685ce1d608fa8dddd242b7711