Back to Search
Start Over
Comparative analysis of patients with upper urinary tract urothelial carcinoma in black-foot disease endemic and non-endemic area
- Source :
- BMC Cancer, BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background A high incidence of upper urinary tract urothelial carcinoma has been reported in the southwestern area of Taiwan, where arsenic water contamination was considered the main cause. However, there is no definite proof to show a correlation between arsenic water contamination and upper urinary tract urothelial carcinoma. To investigate the clinical and epidemiological features of patients with upper urinary tract urothelial carcinoma between arsenic water endemic and non-endemic areas, we analyzed patients in terms of characteristics, stratified overall survival, disease-free survival, and cancer-specific survival. Methods The records of a total of 1194 patients diagnosed with upper urinary tract urothelial carcinoma were retrospectively reviewed. Clinical data and current medical status were collected from the medical records. Statistical analyses were performed to determine the clinical variables and stratified survival curves between endemic and non-endemic groups. Results Female predominance was revealed in both endemic and non-endemic groups (male:female ratio = 1:1.2–1.4). No statistical differences were found in histological types, staging, and tumor size between the two groups. Nonetheless, patients with characteristics of aging and having end-stage renal disease were outnumbered in the non-endemic group, while a higher prevalence of previous bladder tumors and more ureteral tumors were found in the endemic group. Adjusted stratified cumulative survival curves suggested a poorer prognosis in endemic patients, especially in disease-free survival of early stage disease. Conclusions A higher mortality rate with more previous bladder cancer history and ureteral tumors was seen in patients with upper urinary tract urothelial carcinoma residing in the arsenic water contamination area. This may be attributed to the long-term carcinogenic effect of arsenic underground water.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Endemic Diseases
Taiwan
030232 urology & nephrology
lcsh:RC254-282
Gastroenterology
Arsenicals
Disease-Free Survival
Arsenic
03 medical and health sciences
0302 clinical medicine
Risk Factors
Surgical oncology
Internal medicine
Epidemiology
Water Pollution, Chemical
Genetics
Humans
Medicine
Survival analysis
Aged
Retrospective Studies
Upper urinary tract
Peripheral Vascular Diseases
Carcinoma, Transitional Cell
Bladder cancer
Geography
Ureteral Neoplasms
business.industry
Upper urinary tract urothelial carcinoma
Incidence
Incidence (epidemiology)
Mortality rate
Medical record
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
medicine.disease
Kidney Neoplasms
Black foot disease
Oncology
030220 oncology & carcinogenesis
Female
business
Clinicopathological features
Research Article
Subjects
Details
- ISSN :
- 14712407
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....0e4b4823348bc85d4a735153ff3d17d8