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Cross-sectional associations between dietary intake and carotid intima media thickness in type 2 diabetes: baseline data from a randomised trial
- Source :
- BMJ Open
- Publication Year :
- 2017
-
Abstract
- Objective To assess associations between dietary intake and carotid intima media thickness (CIMT) by carotid ultrasound (CUS), a surrogate marker of cardiovascular disease (CVD) risk, in those with type 2 diabetes. Design Cross-sectional analysis of baseline data from 325 participants from three randomised controlled trials collected in the same way. Setting Risk Factor Modification Centre, St. Michael9s Hospital, Toronto, Canada. Participants 325 participants with type 2 diabetes, taking oral antidiabetic agents, with an HbA1c between 6.5% and 8.0% at screening, without a recent cardiovascular event. Main outcome measures CIMT by CUS and associations with dietary intake from 7-day food records, as well as anthropometric measures and fasting serum samples. Results CIMT was significantly inversely associated with dietary pulse intake (β=−0.019, p=0.009), available carbohydrate (β=−0.004, p=0.008), glycaemic load (β=−0.001, p=0.007) and starch (β=−0.126, p=0.010), and directly associated with total (β=0.004, p=0.028) and saturated (β=0.012, p=0.006) fat intake in multivariate regression models adjusted for age, smoking, previous CVD event, blood pressure medication, antidiabetic medication and ultrasonographer. Conclusions Lower CIMT was significantly associated with greater consumption of dietary pulses and carbohydrates and lower total and saturated fat intake, suggesting a potential role for diet in CVD risk management in type 2 diabetes. Randomised controlled trials are anticipated to explore these associations further. Trial registration number NCT01063374.
- Subjects :
- Male
medicine.medical_specialty
Canada
NUTRITION & DIETETICS
030209 endocrinology & metabolism
Disease
Type 2 diabetes
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Medicine
Humans
Risk factor
Nutrition and Metabolism
business.industry
Surrogate endpoint
DIABETES & ENDOCRINOLOGY
Dietary intake
Research
General Medicine
Anthropometry
Middle Aged
medicine.disease
3. Good health
Diet
Blood pressure
Endocrinology
Cross-Sectional Studies
Intima-media thickness
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Female
business
Subjects
Details
- ISSN :
- 20446055
- Volume :
- 7
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- BMJ open
- Accession number :
- edsair.doi.dedup.....0e26a68ad8ea0c4e9400b3c4964346bd