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Laboratory findings in COVID-19 diagnosis and prognosis
- Source :
- Clinica Chimica Acta, Clinica Chimica Acta; International Journal of Clinical Chemistry
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Highlights • Laboratory medicine fulfill a great assistance to early detection of SARAS-CoV-2. • Laboratory abnormalities could discriminate between severe and non-severe COVID-19 patients. • Abnormal laboratory parameters mirror the evolution of COVID-19 toward an unfavorable outcome. • Lymphopenia and increased D-dimer, LDH, ALT, AST reflect poor prognosis in COVID-19.<br />Background Since its first description, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), formerly known as 2019-nCoV, has attracted tremendous attention in a short period of time as the death toll and number of confirmed cases grows unceasingly. Methods To provide a better understanding of the importance of abnormal laboratory findings in COVID-19 diagnosis and prognosis, we searched the Scopus, PubMed, and Web of Science medical databases and selected 19 articles (totaling 2988 patients, 484 of whom [16.1%] had severe disease) that reported panels of laboratory examinations in patients with COVID-19. Results Although in vitro diagnostics, primarily using PCR- and ELISA-based methods, efficiently contribute to the etiological identification of SARS-CoV-2 infection, we suggest that laboratory medicine may also be of significant assistance when differentiating between severe and non-severe COVID-19. Conclusion When we wrote this article, our ability to provide a definitive conclusion may have been adversely affected by some limitations, such as the low sample size, differently applied methods, dissimilar reference ranges, non-synchronized representations of results, and variety of the patients’ panels. Despite the limitations, the analysis of the current scientific literature demonstrates the value of laboratory parameters as simple, rapid, and cost-effective biomarkers in COVID-19 patients.
- Subjects :
- 0301 basic medicine
Laboratory findings
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia, Viral
Clinical Biochemistry
Medical laboratory
Biochemistry
Article
03 medical and health sciences
0302 clinical medicine
Diagnosis
medicine
Humans
In patient
Intensive care medicine
Pandemics
Biochemistry, medical
SARS-CoV-2
Clinical Laboratory Techniques
business.industry
Biochemistry (medical)
COVID-19
General Medicine
Prognosis
Coronavirus
030104 developmental biology
Death toll
Sample size determination
030220 oncology & carcinogenesis
Etiology
Coronavirus Infections
business
Abnormal laboratory findings
Subjects
Details
- Language :
- English
- ISSN :
- 00098981
- Database :
- OpenAIRE
- Journal :
- Clinica Chimica Acta
- Accession number :
- edsair.doi.dedup.....0e13d25ba9602f261f44ea391020715d
- Full Text :
- https://doi.org/10.1016/j.cca.2020.08.019