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Clinical Potential of Histone Deacetylase Inhibitors as Stand Alone Therapeutics and in Combination with other Chemotherapeutics or Radiotherapy for Cancer
- Source :
- Epigenetics. 1:121-126
- Publication Year :
- 2006
- Publisher :
- Informa UK Limited, 2006.
-
Abstract
- Histone deacetylase inhibitors are emerging as a new class of cancer chemotherapeutics and already are being heralded as the first anti-cancer drugs targeting the epigenome. Through histone hyperacetylation-mediated changes in chromatin conformation and gene expression, histone deacetylase inhibitors induce differentiation, cell cycle arrest, apoptosis, growth inhibition and cell death, which are more pronounced in transformed cell-lines than in normal cells. Additional anti-cancer effects of HDAC inhibitors include inhibition of migration, invasion and angiogenesis in vivo. Indeed, clinical anti-cancer activity has been observed using HDAC inhibitors as single agents or in combination with conventional chemotherapeutics, in phase I and II trials. Furthermore, numerous preclinical studies are suggesting a potential clinical role for HDAC inhibitors in radiotherapy either as radiation sensitizers or protectors. In this article the molecular basis for the clinical potential of HDAC inhibitors, either as stand alone cancer therapeutics or in combination with other chemotherapy agents or ionizing radiation will be overviewed.
- Subjects :
- Cancer Research
Cell cycle checkpoint
Angiogenesis
Antineoplastic Agents
Histones
chemistry.chemical_compound
Neoplasms
Radiation, Ionizing
medicine
Homeostasis
Humans
Enzyme Inhibitors
Molecular Biology
Histone Acetyltransferases
Histone deacetylase 5
biology
Genetic Variation
Cancer
Epigenome
medicine.disease
Histone Deacetylase Inhibitors
Histone
chemistry
Biochemistry
biology.protein
Cancer research
Histone deacetylase
Growth inhibition
Subjects
Details
- ISSN :
- 15592308 and 15592294
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Epigenetics
- Accession number :
- edsair.doi.dedup.....0e0776adc12f41ac1eeaf64d6d17fe0e