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Cancer incidence within a cohort occupationally exposed to asbestos: a study of dose-response relationships
- Source :
- Occupational and Environmental Medicine. 68:832-836
- Publication Year :
- 2011
- Publisher :
- BMJ, 2011.
-
Abstract
- Objectives The aim of our study was to analyse the dose–response relationship between occupational asbestos exposure and risk of cancer. Methods Our study was a retrospective morbidity study based on 2024 subjects occupationally exposed to asbestos, conducted over the period 1 January 1978 to 31 December 2004. Analysis of the dose–response relationship between occupational asbestos exposure, as a time-dependant variable, and risk of cancer was performed using a Cox model. In order to account for the effect of latency, we conducted the analysis with a lag of 10 years. Results 285 cases of cancers were observed in our cohort. The relative risk of pleuro-peritoneal mesothelioma, lung cancer and colorectal cancer associated with asbestos exposure, adjusted for age as a time-dependant variable and for sex, was correlated with exposure intensity (or average exposure level, AEL). The risk of cancer, whatever the anatomical site, did not increase with the duration of exposure to asbestos. Conclusion While confirming the established relationship between asbestos exposure and pleuropulmonary and peritoneal cancers, this study also suggests a causal relationship between asbestos exposure and colorectal cancer.
- Subjects :
- Adult
Male
Mesothelioma
Oncology
medicine.medical_specialty
Pathology
Lung Neoplasms
medicine.disease_cause
Risk Assessment
Asbestos
Neoplasms
Occupational Exposure
Internal medicine
medicine
Humans
Lung cancer
Peritoneal Neoplasms
Retrospective Studies
business.industry
Incidence
Incidence (epidemiology)
Public Health, Environmental and Occupational Health
Cancer
Retrospective cohort study
medicine.disease
Occupational Diseases
Relative risk
Cohort
Carcinogens
Female
France
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 13510711
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Occupational and Environmental Medicine
- Accession number :
- edsair.doi.dedup.....0e028e33301581f69aaf2a9abaef137a