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Sphingolipids as multifaceted mediators in ovarian cancer
- Publication Year :
- 2021
- Publisher :
- US : Elsevier, 2021.
-
Abstract
- Ovarian cancer is the most lethal gynaecological malignancy. It is commonly diagnosed at advanced stage when it has metastasised to the abdominal cavity and treatment becomes very challenging. While current standard therapy involving debulking surgery and platinum + taxane-based chemotherapy is associated with high response rates initially, the large majority of patients relapse and ultimately succumb to chemotherapy-resistant disease. In order to improve survival novel strategies for early detection and therapeutics against treatment-refractory disease are urgently needed. A promising new target against ovarian cancer is the sphingolipid pathway which is commonly hijacked in cancer to support cell proliferation and survival and has been shown to promote chemoresistance and metastasis in a wide range of malignant neoplasms. In particular, the sphingosine kinase 1-sphingosine 1-phosphate receptor 1 axis has been shown to be altered in ovarian cancer in multiple ways and therefore represents an attractive therapeutic target. Here we review the roles of sphingolipids in ovarian cancer progression, metastasis and chemoresistance, highlighting novel strategies to target this pathway that represent potential avenues to improve patient survival. Refereed/Peer-reviewed
- Subjects :
- 0301 basic medicine
autophagy
medicine.medical_treatment
Sphingosine kinase
Disease
Metastasis
03 medical and health sciences
0302 clinical medicine
Sphingosine
Medicine
Animals
Humans
ceramide
Sphingosine-1-Phosphate Receptors
Ovarian Neoplasms
Chemotherapy
Taxane
business.industry
apoptosis
Cancer
chemoresistance
Cell Biology
Debulking
medicine.disease
Neoplasm Proteins
Phosphotransferases (Alcohol Group Acceptor)
030104 developmental biology
ovarian cancer
030220 oncology & carcinogenesis
Cancer research
Female
sphingolipid
Lysophospholipids
business
Ovarian cancer
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0df9c255d3207e5c26271855a393bd7b