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Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci

Authors :
Jeanette Erdmann
Klaus Berger
André G. Uitterlinden
Andre Franke
Nathalie van der Velde
Yvonne Jockel-Schneider
Matthias Laudes
Jürgen Wellmann
Bruno G. Loos
Alexander Teumer
Kimon Divaris
Wolfgang Lieb
Matthias Munz
Gesa M. Richter
Ingmar Staufenbiel
Corinna Bruckmann
Lisette C. P. G. M. de Groot
Arne S. Schaefer
Christian Graetz
Ilyas Ahmad
Bastian Krone
Thomas Kocher
Per Hoffmann
Henrik Dommisch
Steven Offenbacher
Birte Holtfreter
Søren Jepsen
Geriatrics
APH - Aging & Later Life
AMS - Ageing & Morbidty
Parodontologie (OII, ACTA)
Internal Medicine
Periodontology
Source :
European journal of human genetics, 27(1), 102-113. Nature Publishing Group, Munz, M, Richter, G M, Loos, B G, Jepsen, S, Divaris, K, Offenbacher, S, Teumer, A, Holtfreter, B, Kocher, T, Bruckmann, C, Jockel-Schneider, Y, Graetz, C, Ahmad, I, Staufenbiel, I, van der Velde, N, Uitterlinden, A G, de Groot, L C P G M, Wellmann, J, Berger, K, Krone, B, Hoffmann, P, Laudes, M, Lieb, W, Franke, A, Erdmann, J, Dommisch, H & Schaefer, A S 2019, ' Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci ', European Journal of Human Genetics, vol. 27, no. 1, pp. 102-113 . https://doi.org/10.1038/s41431-018-0265-5, European Journal of Human Genetics 27 (2019) 1, European Journal of Human Genetics, 27(1), 102-113. Nature Publishing Group, European Journal of Human Genetics, 27(1), 102-113
Publication Year :
2019

Abstract

Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. It is classified into the widespread moderate form chronic periodontitis (CP) and the rare early-onset and severe phenotype aggressive periodontitis (AgP). These different disease manifestations are thought to share risk alleles and predisposing environmental factors. To obtain novel insights into the shared genetic etiology and the underlying molecular mechanisms of both forms, we performed a two step-wise meta-analysis approach using genome-wide association studies of both phenotypes. Genotypes from imputed genome-wide association studies (GWAS) of AgP and CP comprising 5,095 cases and 9,908 controls of North-West European genetic background were included. Two loci were associated with periodontitis at a genome-wide significance level. They located within the pseudogene MTND1P5 on chromosome 8 (rs16870060-G, P = 3.69 × 10(−9), OR = 1.36, 95% CI = [1.23–1.51]) and intronic of the long intergenic non-coding RNA LOC107984137 on chromosome 16, downstream of the gene SHISA9 (rs729876-T, P = 9.77 × 10(−9), OR = 1.24, 95% CI = [1.15–1.34]). This study identified novel risk loci of periodontitis, adding to the genetic basis of AgP and CP.

Details

Language :
English
ISSN :
10184813
Volume :
27
Issue :
1
Database :
OpenAIRE
Journal :
European Journal of Human Genetics
Accession number :
edsair.doi.dedup.....0df74e229243d636567ddf9958b6f73a
Full Text :
https://doi.org/10.1038/s41431-018-0265-5