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Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci
- Source :
- European journal of human genetics, 27(1), 102-113. Nature Publishing Group, Munz, M, Richter, G M, Loos, B G, Jepsen, S, Divaris, K, Offenbacher, S, Teumer, A, Holtfreter, B, Kocher, T, Bruckmann, C, Jockel-Schneider, Y, Graetz, C, Ahmad, I, Staufenbiel, I, van der Velde, N, Uitterlinden, A G, de Groot, L C P G M, Wellmann, J, Berger, K, Krone, B, Hoffmann, P, Laudes, M, Lieb, W, Franke, A, Erdmann, J, Dommisch, H & Schaefer, A S 2019, ' Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci ', European Journal of Human Genetics, vol. 27, no. 1, pp. 102-113 . https://doi.org/10.1038/s41431-018-0265-5, European Journal of Human Genetics 27 (2019) 1, European Journal of Human Genetics, 27(1), 102-113. Nature Publishing Group, European Journal of Human Genetics, 27(1), 102-113
- Publication Year :
- 2019
-
Abstract
- Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. It is classified into the widespread moderate form chronic periodontitis (CP) and the rare early-onset and severe phenotype aggressive periodontitis (AgP). These different disease manifestations are thought to share risk alleles and predisposing environmental factors. To obtain novel insights into the shared genetic etiology and the underlying molecular mechanisms of both forms, we performed a two step-wise meta-analysis approach using genome-wide association studies of both phenotypes. Genotypes from imputed genome-wide association studies (GWAS) of AgP and CP comprising 5,095 cases and 9,908 controls of North-West European genetic background were included. Two loci were associated with periodontitis at a genome-wide significance level. They located within the pseudogene MTND1P5 on chromosome 8 (rs16870060-G, P = 3.69 × 10(−9), OR = 1.36, 95% CI = [1.23–1.51]) and intronic of the long intergenic non-coding RNA LOC107984137 on chromosome 16, downstream of the gene SHISA9 (rs729876-T, P = 9.77 × 10(−9), OR = 1.24, 95% CI = [1.15–1.34]). This study identified novel risk loci of periodontitis, adding to the genetic basis of AgP and CP.
- Subjects :
- 0301 basic medicine
Medizin
Genome-wide association study
Disease
Biology
Article
03 medical and health sciences
0302 clinical medicine
Chromosome 16
Genotype
Genetics
medicine
Aggressive periodontitis
Humans
Life Science
Periodontitis
Genetics (clinical)
Genetic association
VLAG
Global Nutrition
Wereldvoeding
Polymorphism, Genetic
030206 dentistry
medicine.disease
Chronic periodontitis
030104 developmental biology
Genetic Loci
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 8
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 10184813
- Volume :
- 27
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....0df74e229243d636567ddf9958b6f73a
- Full Text :
- https://doi.org/10.1038/s41431-018-0265-5