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Nitric oxide production is increased in patients with rheumatoid arthritis but does not correlate with laboratory parameters of disease activity
- Source :
- Clinica chimica acta; international journal of clinical chemistry. 336(1-2)
- Publication Year :
- 2003
-
Abstract
- Background: To investigate whether nitric oxide (NO) production correlates with laboratory parameters of disease activity in patients with rheumatoid arthritis (RA), we measured serum nitrates and nitrites (NOx) concentrations, rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and serum iron markers in 115 RA patients. Methods: Serum NOx concentrations were determined after reduction of nitrates to nitrites using the Griess reaction. Serum transferrin receptor (sTfR) and serum ferritin were assayed using an enzyme immunoassay and a chemiluminescence method. Correlation coefficients of CRP, ESR, and RF vs. NOx concentrations were assessed. Results: Serum NOx concentrations averaged 208.3±126.8 μmol/l in RA patients without iron deficiency (n=72) and 267.9±148.4 μmol/l in RA patients with iron deficiency (n=43), which were significantly higher than those of healthy controls (32.7±14.3 μmol/l, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Iron
Clinical Biochemistry
Statistics as Topic
Blood Sedimentation
Nitric Oxide
Biochemistry
Nitric oxide
Arthritis, Rheumatoid
chemistry.chemical_compound
Griess test
Rheumatoid Factor
Internal medicine
medicine
Rheumatoid factor
Humans
Aged
Hematologic Tests
biology
medicine.diagnostic_test
Chemistry
Biochemistry (medical)
C-reactive protein
General Medicine
Iron deficiency
Iron Deficiencies
Middle Aged
medicine.disease
Endocrinology
C-Reactive Protein
Erythrocyte sedimentation rate
Rheumatoid arthritis
Case-Control Studies
Ferritins
biology.protein
Serum iron
Female
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 336
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Accession number :
- edsair.doi.dedup.....0df2ef2cbb60300e06bd243807c1b18d