Respiratory symptoms were associated with lower spirometry results during the first examination of WTC responders

Objective: Determine if World Trade Center (WTC) disaster responders had lowerlungfunctionandhigherbronchodilatorresponsivenessthanthosewith respiratory symptoms and conditions. Methods: We evaluated cardinal respiratory symptoms (dyspnea, wheezing, dry cough, productive cough) and determinedthedifferenceinFEV1,FVC, andbronchodilatorresponsiveness. Results: All respiratory symptoms were associated with a lower FEV1 and FVC, and a larger bronchodilator response. Responders reporting chronic productive cough, starting during WTC work and persisting, had a mean FEV1 109 mL lower than those without chronic persistent cough; their odds of having abnormally low FEV1 was 1.40 times higher; and they were 1.65 times as likely to demonstrate bronchodilator responsiveness. Conclusions: Responders reporting chronic persistent cough, wheezing or dyspnea at first medical examination were more likely to have lower lung function and bronchodilator responsiveness.