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Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma
- Source :
- Asian Pacific journal of cancer prevention : APJCP. 16(12)
- Publication Year :
- 2015
-
Abstract
- FADS1 (fatty acid desaturase 1) plays a crucial role in fatty acid metabolism, and it was recently reported to be involved in tumorigenesis. However, the role of FADS1 expression in esophageal squamous cell carcinoma (ESCC) remains unknown. In the current study, we investigated the expression and clinical pathologic and prognostic significance of FADS1 in ESCC. Immunohistochemical analyses revealed that 58.2% (146/251) of the ESCC tissues had low levels of FADS1 expression, whereas 41.8% (105/251) exhibited high levels of FADS1 expression. In positive cases, FADS1 expression was detected in the cytoplasm of cells. Correlation analyses demonstrated that FADS1 expression was significantly correlated with tumor location (p=0.025) but not with age, gender, histological grade, tumor status, nodal status or TNM staging. Furthermore, patients with tumors expressing high levels of FADS1had a longer disease-free survival time (p
- Subjects :
- Oncology
Fatty Acid Desaturases
Male
Cancer Research
medicine.medical_specialty
Esophageal Neoplasms
Epidemiology
FADS1
Biology
medicine.disease_cause
Immunoenzyme Techniques
Tumor Status
Delta-5 Fatty Acid Desaturase
Internal medicine
medicine
Carcinoma
Biomarkers, Tumor
Humans
Survival rate
Neoplasm Staging
Regulation of gene expression
Public Health, Environmental and Occupational Health
Middle Aged
medicine.disease
Prognosis
Gene Expression Regulation, Neoplastic
Survival Rate
Carcinoma, Squamous Cell
Immunohistochemistry
Biomarker (medicine)
Female
Neoplasm Grading
Carcinogenesis
Follow-Up Studies
Subjects
Details
- ISSN :
- 2476762X
- Volume :
- 16
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Accession number :
- edsair.doi.dedup.....0dde62c223c8f139033490b3561e6d91