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Expanded Geographical Distribution of the N Family of Mycobacterium tuberculosis Strains within the United States
- Source :
- Journal of Clinical Microbiology. 42:1064-1068
- Publication Year :
- 2004
- Publisher :
- American Society for Microbiology, 2004.
-
Abstract
- The N and W-Beijing families of Mycobacterium tuberculosis are phylogenetically closely related. The ability of the W-Beijing family to rapidly cause widespread disease is well described; however, few outbreaks involving the N family have been reported outside the New York City, N.Y., area. During 2002 to 2003, Seattle, Wash., experienced a rapidly expanding tuberculosis outbreak involving 38 persons in a 23-month period. The outbreak strain, SBRI9, exhibited the genotypic properties of the N family. Its IS 6110 restriction fragment length polymorphism pattern was identical or nearly identical to those of two N family strains that were responsible for clusters of tuberculosis cases, including a large nosocomial outbreak, in New York City and New Jersey from 1989 to 1990. It was also identical to strains involved in late 1990s tuberculosis cases in Michigan, Maryland, and Arkansas. Further monitoring of the N family may show that it shares with the W-Beijing family the propensity to spread rapidly, suggesting that this characteristic evolved prior to the divergence of the two genetic lineages.
- Subjects :
- Washington
Microbiology (medical)
Tuberculosis
Genotype
Distribution (economics)
Biology
Disease Outbreaks
Mycobacterium tuberculosis
medicine
Humans
Phylogeny
Genetics
Geography
business.industry
Strain (biology)
Widespread Disease
Outbreak
Mycobacteriology and Aerobic Actinomycetes
biology.organism_classification
medicine.disease
Introns
United States
Centers for Disease Control and Prevention, U.S
Restriction fragment length polymorphism
business
Polymorphism, Restriction Fragment Length
Subjects
Details
- ISSN :
- 1098660X and 00951137
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....0dd866f34ab1de8bd25a21383a58d8be