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Plasma 25(OH)D Concentrations and Gestational Diabetes Mellitus among Pregnant Women in Taiwan
- Source :
- Nutrients, Nutrients, Vol 13, Iss 2538, p 2538 (2021), Volume 13, Issue 8
- Publication Year :
- 2021
-
Abstract
- Vitamin D’s function in the development of gestational diabetes mellitus (GDM) is not consistent in the literature. We examined the association between maternal plasma 25(OH)D concentration and GDM risk. A national cross-sectional study (1497 pregnant women) was conducted between 2017 and 2019 across Taiwan. Blood samples were drawn at recruitment to assess 25(OH)D concentrations, including vitamin D deficiency (VDD) (&lt<br />20 ng/mL), insufficiency (&lt<br />32 ng/mL), and sufficiency (≥32 ng/mL). GDM was detected from 24 to 28 weeks of gestation with the results extracted from the antenatal visit records. The prevalence of GDM was 2.9%. Logistic model analysis showed that 25(OH)D concentrations were not significantly associated with the risk of GDM (adjusted odds ratio (AOR) = 0.97, p = 0.144). However, subjects with VDD had a significantly greater risk of GDM (AOR = 2.26, p = 0.041), but not in those with vitamin D insufficiency (AOR = 1.20, p = 0.655). Furthermore, cubic piecewise spline regression was used to explore the relationship between five-unit intervals of 25(OH)D and the predicted probability of GDM. As the proportion of GDM increased for low 25(OH)D concentrations, it decreased at moderate concentrations and increased again at higher concentrations. These findings revealed a nonlinear relationship between 25(OH)D and GDM risk. VDD would be risky for GDM occurrence.
- Subjects :
- Adult
medicine.medical_specialty
endocrine system diseases
vitamin D deficiency
Taiwan
030209 endocrinology & metabolism
Logistic regression
Risk Assessment
Article
03 medical and health sciences
0302 clinical medicine
Pregnancy
Risk Factors
Prenatal Diagnosis
Vitamin D and neurology
Odds Ratio
Medicine
Humans
TX341-641
030212 general & internal medicine
Vitamin D
Nutrition and Dietetics
business.industry
Obstetrics
Nutrition. Foods and food supply
nutritional and metabolic diseases
Prenatal Care
Odds ratio
25(OH)D concentration
medicine.disease
female genital diseases and pregnancy complications
gestational diabetes mellitus
Gestational diabetes
Diabetes, Gestational
Cross-Sectional Studies
Logistic Models
Gestation
Female
business
pregnant women
Food Science
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....0dd6fbcf36b2b3928cb89c12765453a8