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Ferric Ion Driven Assembly of Catalaseālike Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors
- Source :
- Angewandte Chemie International Edition. 59:23228-23238
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- A facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed. The process involved Fe3+ -driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding a zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during the Fe3+ -promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc-Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe3+ could catalyze the transformation of H2 O2 enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc-Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc-Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.
- Subjects :
- Indoles
Macromolecular Substances
Surface Properties
medicine.medical_treatment
Mice, Nude
Antineoplastic Agents
Photodynamic therapy
Isoindoles
010402 general chemistry
Ferric Compounds
01 natural sciences
Catalysis
Mice
chemistry.chemical_compound
In vivo
Organometallic Compounds
medicine
Animals
Humans
Photosensitizer
Acriflavine
Particle Size
Cell Proliferation
Ions
chemistry.chemical_classification
Photosensitizing Agents
biology
010405 organic chemistry
Optical Imaging
General Medicine
General Chemistry
Hypoxia-Inducible Factor 1, alpha Subunit
Combinatorial chemistry
0104 chemical sciences
Amino acid
Photochemotherapy
chemistry
Zinc Compounds
Catalase
biology.protein
Phthalocyanine
Nanoparticles
Tumor Hypoxia
HT29 Cells
Cysteine
Subjects
Details
- ISSN :
- 15213773 and 14337851
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....0dd63121f0b697955522287d9095e84c