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Circulating Long Noncoding RNA Signatures Associate With Incident Diabetes in Older Adults: A Prospective Analysis From the VITA Cohort Study
- Source :
- Diabetes Care. 46:1239-1244
- Publication Year :
- 2023
- Publisher :
- American Diabetes Association, 2023.
-
Abstract
- OBJECTIVE Long noncoding RNAs (lncRNAs) are involved in diabetogenesis in experimental models, yet their role in humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes in older adults. RESEARCH DESIGN AND METHODS A preselected panel of lncRNAs was measured in serum of individuals without diabetes (n = 296) from the Vienna Transdanube Aging study, a prospective community-based cohort study. Participants were followed up over 7.5 years. A second cohort of individuals with and without type 2 diabetes (n = 90) was used to validate our findings. RESULTS Four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with incident type 2 diabetes and linked to hemoglobin A1c trajectories throughout the 7.5-year follow-up. Similar results (for MIAT and PLUTO also in combined analysis) were obtained in the validation cohort. CONCLUSIONS We found a set of circulating lncRNAs that independently portends incident type 2 diabetes in older adults years before disease onset.
- Subjects :
- Advanced and Specialized Nursing
2902 Advanced and Specialized Nursing
Endocrinology, Diabetes and Metabolism
610 Medicine & health
10058 Department of Child and Adolescent Psychiatry
Internal Medicine
11459 Center for Molecular Cardiology
Diabetes and Metabolism
2712 Endocrinology, Diabetes and Metabolism
Endocrinology
2724 Internal Medicine
10076 Center for Integrative Human Physiology
10209 Clinic for Cardiology
10064 Neuroscience Center Zurich
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....0dd1f020c38c11e8976ab4eb7d0f46e9