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Circulating Long Noncoding RNA Signatures Associate With Incident Diabetes in Older Adults: A Prospective Analysis From the VITA Cohort Study

Authors :
Wenzl, Florian A
Mengozzi, Alessandro
Mohammed, Shafeeq A
Pugliese, Nicola Riccardo
Mongelli, Alessia
Gorica, Era
Ambrosini, Samuele
Riederer, Peter
Fischer, Peter
Hinterberger, Margareta
Puspitasari, Yustina
Lüscher, Thomas F
Camici, Giovanni G
Matter, Christian M
Fadini, Gian Paolo
Virdis, Agostino
Masi, Stefano
Ruschitzka, Frank
Grünblatt, Edna
Paneni, Francesco
Costantino, Sarah
University of Zurich
Paneni, Francesco
Costantino, Sarah
Source :
Diabetes Care. 46:1239-1244
Publication Year :
2023
Publisher :
American Diabetes Association, 2023.

Abstract

OBJECTIVE Long noncoding RNAs (lncRNAs) are involved in diabetogenesis in experimental models, yet their role in humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes in older adults. RESEARCH DESIGN AND METHODS A preselected panel of lncRNAs was measured in serum of individuals without diabetes (n = 296) from the Vienna Transdanube Aging study, a prospective community-based cohort study. Participants were followed up over 7.5 years. A second cohort of individuals with and without type 2 diabetes (n = 90) was used to validate our findings. RESULTS Four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with incident type 2 diabetes and linked to hemoglobin A1c trajectories throughout the 7.5-year follow-up. Similar results (for MIAT and PLUTO also in combined analysis) were obtained in the validation cohort. CONCLUSIONS We found a set of circulating lncRNAs that independently portends incident type 2 diabetes in older adults years before disease onset.

Details

ISSN :
19355548 and 01495992
Volume :
46
Database :
OpenAIRE
Journal :
Diabetes Care
Accession number :
edsair.doi.dedup.....0dd1f020c38c11e8976ab4eb7d0f46e9