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Concurrent Radiation and Modern Systemic Therapies for Breast Cancer: An Ever-Expanding Frontier
- Source :
- Clinical Breast Cancer. 21:120-127
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Radiotherapy is a critical tool for reducing locoregional recurrence, extending survival, and palliating symptoms in patients with breast cancer. With an ever-expanding armamentarium of systemic agents available, and an increasing trend toward the use of hypofractionated radiation regimens, it can be difficult to determine the safety of concurrent therapy. In particular, new targeted agents in both the adjuvant and metastatic setting have limited prospective or long-term data demonstrating safety when delivered concurrently with radiotherapy. Other systemic agents, including chemotherapy and endocrine therapy, are also important components of the overall treatment strategy for localized and metastatic breast cancer, and are often delivered concurrently with radiation in certain clinical scenarios. This review explores the safety, efficacy, and pitfalls of delivering radiation in conjunction with systemic therapies for breast cancer.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Antineoplastic Agents
Breast Neoplasms
Targeted therapy
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Adjuvant therapy
Humans
Medicine
Chemotherapy
business.industry
Endocrine therapy
medicine.disease
Combined Modality Therapy
Metastatic breast cancer
Neoadjuvant Therapy
Biological Therapy
Radiation therapy
030104 developmental biology
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
Female
Radiotherapy, Adjuvant
business
Adjuvant
Subjects
Details
- ISSN :
- 15268209
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Clinical Breast Cancer
- Accession number :
- edsair.doi.dedup.....0dbd8e33a88b5eeda6bc93ce66cf6a0b