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Lanthanide-Bisphosphonate Coordination Chemistry: Biocompatible Fluorescent Labeling Strategy for Hydrogel
- Publisher :
- AMER CHEMICAL SOC
-
Abstract
- Fluorescent hydrogel demonstrates great potential in biomedical field as chemo/biosensor and bioimaging agent Herein, a labeling strategy based on coordination bond between lanthanide and bisphosphonate (BP) is reported to form fluorescent hydrogel. Specifically, BP-acrylamide compound was synthesized as organic "antenna" to stabilize lanthanide fluorescent signal. The coordination chemical structure and interaction energy between lanthanide (Eu3+) and BP-acrylamide ligand were obtained using density functional theory (DFT) calculations, indicating strong binding of Eu3+ ions with phosphonic oxygen atoms. Additionally, the lanthanide center dot BP complex could be chemically incorporated through acrylamide group into poly(ethylene glycol) diacrylate network to fabricate fluorescent hydrogels. The dynamic inherent properties of lanthanide center dot BP coordination bonds imparted the presented hydrogel's multistimuli-responsive properties against pH value and metal ions. The animal experiments revealed lanthanide-BP fluorescent hydrogel of great biocompatibilities and long-term structure stabilities in vivo. Therefore, we provide a facile coordination labeling strategy to develop biocompatible fluorescent hydrogel that presents potential for biomedical sensing and imaging applications.
- Subjects :
- Lanthanide
basis-sets
bisphosphonate
lanthanide
Biocompatibility
Biomedical Engineering
Nanotechnology
in-vitro
Coordination complex
Biomaterials
biocompatibility
dots
molecular-orbital methods
polymers
chemistry.chemical_classification
Chemistry
fluorescent hydrogel
Biochemistry (medical)
General Chemistry
Biocompatible material
Fluorescence
Fluorescent labelling
phosphorescence
coordination chemistry
gaussian-type basis
Biosensor
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0db7a33d35bfd801035ea2393327cb7b